| Literature DB >> 20447817 |
Wenqian Huo1, Keqin Zhang, Zhilin Nie, Qiansheng Li, Fengshuo Jin.
Abstract
Kidney injury molecule-1 (KIM-1), a recently discovered transmembrane protein, is expressed in dedifferentiated proximal renal tubular epithelial cells in damaged regions. It may participate in the progress of renal injury or repair. Many studies have illustrated the different functions of KIM-1 in various renal diseases including protective functions in acute kidney injury and damaging functions in chronic kidney disease. Although, the exact functions of KIM-1 still remain unclear, some scientists speculate that KIM-1 is expected to be a therapeutic target for kidney injury. In this review, some of the known features and functions of KIM-1 are highlighted. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20447817 DOI： 10.1016/j.trre.2010.02.002
Source DB: PubMed Journal: Transplant Rev (Orlando) ISSN： 0955-470X Impact factor: 3.943