OBJECTIVE: Six months after acute infectious mononucleosis (IM), 13% of adolescents meet criteria for chronic fatigue syndrome (CFS). We measured exercise tolerance in adolescents with CFS and control subjects 6 months after IM. STUDY DESIGN: Twenty-one adolescents with CFS 6 months after IM and 21 recovered control subjects performed a maximal incremental exercise tolerance test with breath-by-breath gas analysis. Values expressed are mean+/-standard deviation. RESULTS: The adolescents diagnosed with CFS and control subjects did not differ in age, weight, body mass index, or peak work capacity. Lower oxygen consumption peak percent of predicted was seen in adolescents with CFS compared with control subjects (CFS 99.3+/-16.6 vs control subject 110.7+/-19.9, P=.05). Peak oxygen pulse also was lower in adolescents with CFS compared with recovered control subjects (CFS 12.4+/-2.9 vs control subjects 14.9+/-4.3, P=.03). CONCLUSIONS: Adolescents with CFS 6 months after IM have a lower degree of fitness and efficiency of exercise than recovered adolescents. Whether these abnormal exercise findings are a cause or effect of CFS is unknown. IM can lead to both fatigue and measurable changes in exercise testing in a subset of adolescents. Copyright (c) 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: Six months after acute infectious mononucleosis (IM), 13% of adolescents meet criteria for chronic fatigue syndrome (CFS). We measured exercise tolerance in adolescents with CFS and control subjects 6 months after IM. STUDY DESIGN: Twenty-one adolescents with CFS 6 months after IM and 21 recovered control subjects performed a maximal incremental exercise tolerance test with breath-by-breath gas analysis. Values expressed are mean+/-standard deviation. RESULTS: The adolescents diagnosed with CFS and control subjects did not differ in age, weight, body mass index, or peak work capacity. Lower oxygen consumption peak percent of predicted was seen in adolescents with CFS compared with control subjects (CFS 99.3+/-16.6 vs control subject 110.7+/-19.9, P=.05). Peak oxygen pulse also was lower in adolescents with CFS compared with recovered control subjects (CFS 12.4+/-2.9 vs control subjects 14.9+/-4.3, P=.03). CONCLUSIONS: Adolescents with CFS 6 months after IM have a lower degree of fitness and efficiency of exercise than recovered adolescents. Whether these abnormal exercise findings are a cause or effect of CFS is unknown. IM can lead to both fatigue and measurable changes in exercise testing in a subset of adolescents. Copyright (c) 2010 Mosby, Inc. All rights reserved.
Authors: Charli Sargent; Garry C Scroop; Peter M Nemeth; Richard B Burnet; Jonathan D Buckley Journal: Med Sci Sports Exerc Date: 2002-01 Impact factor: 5.411
Authors: Dane B Cook; Paul R Nagelkirk; Arnold Peckerman; Ashok Poluri; John J Lamanca; Benjamin H Natelson Journal: Med Sci Sports Exerc Date: 2003-04 Impact factor: 5.411
Authors: Evelina Georgiades; Wilhelmina M H Behan; Liam P Kilduff; Marios Hadjicharalambous; Eileen E Mackie; John Wilson; Susan A Ward; Yannis P Pitsiladis Journal: Clin Sci (Lond) Date: 2003-08 Impact factor: 6.124
Authors: Peter C Rowe; Rosemary A Underhill; Kenneth J Friedman; Alan Gurwitt; Marvin S Medow; Malcolm S Schwartz; Nigel Speight; Julian M Stewart; Rosamund Vallings; Katherine S Rowe Journal: Front Pediatr Date: 2017-06-19 Impact factor: 3.418
Authors: Gordon Broderick; Ben Z Katz; Henrique Fernandes; Mary Ann Fletcher; Nancy Klimas; Frederick A Smith; Maurice R G O'Gorman; Suzanne D Vernon; Renee Taylor Journal: J Transl Med Date: 2012-09-13 Impact factor: 5.531
Authors: Jonas Blomberg; Carl-Gerhard Gottfries; Amal Elfaitouri; Muhammad Rizwan; Anders Rosén Journal: Front Immunol Date: 2018-02-15 Impact factor: 7.561
Authors: Ben Z Katz; Simon M Collin; Gabrielle Murphy; Rona Moss-Morris; Vegard Bruun Wyller; Knut-Arne Wensaas; Jeannine L A Hautvast; Chantal P Bleeker-Rovers; Ute Vollmer-Conna; Dedra Buchwald; Renée Taylor; Paul Little; Esther Crawley; Peter D White; Andrew Lloyd Journal: Fatigue Date: 2018-01-19
Authors: Jeanna M Harvey; Gordon Broderick; Alanna Bowie; Zachary M Barnes; Ben Z Katz; Maurice R G O'Gorman; Suzanne D Vernon; Mary Ann Fletcher; Nancy G Klimas; Renee Taylor Journal: BMC Pediatr Date: 2016-04-26 Impact factor: 2.125