Literature DB >> 20447276

The type 2C protein phosphatase FgPtc1p of the plant fungal pathogen Fusarium graminearum is involved in lithium toxicity and virulence.

Linghuo Jiang1, Jingran Yang, Feiyu Fan, Dajun Zhang, Xuli Wang.   

Abstract

Type 2C protein phosphatases (PP2Cs) are monomeric protein serine/threonine phosphatases that play various roles in eukaryotic organisms. In this study, we characterized the PP2C encoded by FgPTC1 in Fusarium graminearum, the major causal agent of Fusarium head blight on wheat and barley. We found that deletion of FgPTC1 delays the mycelium growth of F. graminearum in response to lithium. Consistently, FgPTC1 complemented the function of ScPTC1 in lithium toxicity in Saccharomyces cerevisiae. Furthermore, we showed that deletion of FgPTC1 attenuated the virulence of F. graminearum on wheat. Therefore, FgPTC1 plays an important role in regulating the hyphal growth and virulence of F. graminearum.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20447276      PMCID： PMC6640505          DOI： 10.1111/j.1364-3703.2009.00598.x

Source DB:  PubMed          Journal:  Mol Plant Pathol        ISSN： 1364-3703            Impact factor:   5.663


  34 in total

1.  A novel type 2C protein phosphatase from the human fungal pathogen Candida albicans.

Authors:  L Jiang; M Whiteway; S H Shen
Journal:  FEBS Lett       Date:  2001-11-30       Impact factor: 4.124

2.  The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast.

Authors:  Linghuo Jiang; Malcolm Whiteway; Carlos w Ramos; Jose R Rodriguez-Medina; Shi-Hsiang Shen
Journal:  FEBS Lett       Date:  2002-09-11       Impact factor: 4.124

3.  Genealogical concordance between the mating type locus and seven other nuclear genes supports formal recognition of nine phylogenetically distinct species within the Fusarium graminearum clade.

Authors:  Kerry O'Donnell; Todd J Ward; David M Geiser; H Corby Kistler; Takayuki Aoki
Journal:  Fungal Genet Biol       Date:  2004-06       Impact factor: 3.495

Review 4.  Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs.

Authors:  Todd D Gould; Husseini K Manji
Journal:  Neuropsychopharmacology       Date:  2005-07       Impact factor: 7.853

5.  A mitogen-activated protein kinase gene (MGV1) in Fusarium graminearum is required for female fertility, heterokaryon formation, and plant infection.

Authors:  Zhanming Hou; Chaoyang Xue; Youliang Peng; Talma Katan; H Corby Kistler; Jin-Rong Xu
Journal:  Mol Plant Microbe Interact       Date:  2002-11       Impact factor: 4.171

6.  Comparative pathogenicity of Fusarium graminearum isolates from China revealed by wheat coleoptile and floret inoculations.

Authors:  A-B Wu; H-P Li; C-S Zhao; Y-C Liao
Journal:  Mycopathologia       Date:  2005-08       Impact factor: 2.574

7.  Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1.

Authors:  J Warmka; J Hanneman; J Lee; D Amin; I Ota
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

8.  Functional characterization of the Candida albicans homologue of secretion-associated and Ras-related (Sar1) protein.

Authors:  Linghuo Jiang; Chang-Muk Lee; Shi-Hsiang Shen
Journal:  Yeast       Date:  2002-03-30       Impact factor: 3.239

9.  Gene genealogies reveal global phylogeographic structure and reproductive isolation among lineages of Fusarium graminearum, the fungus causing wheat scab.

Authors:  K O'Donnell; H C Kistler; B K Tacke; H H Casper
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

10.  Analyses of the effects of Rck2p mutants on Pbs2pDD-induced toxicity in Saccharomyces cerevisiae identify a MAP kinase docking motif, and unexpected functional inactivation due to acidic substitution of T379.

Authors:  L Jiang; S Niu; K L Clines; D J Burke; T W Sturgill
Journal:  Mol Genet Genomics       Date:  2004-01-21       Impact factor: 3.291
View more
  6 in total

Review 1.  Type 2C protein phosphatases in fungi.

Authors:  Joaquín Ariño; Antonio Casamayor; Asier González
Journal:  Eukaryot Cell       Date:  2010-11-12

2.  Phosphorylation of Mycobacterium tuberculosis Ser/Thr phosphatase by PknA and PknB.

Authors:  Andaleeb Sajid; Gunjan Arora; Meetu Gupta; Sandeep Upadhyay; Vinay K Nandicoori; Yogendra Singh
Journal:  PLoS One       Date:  2011-03-09       Impact factor: 3.240

3.  A type 2C protein phosphatase FgPtc3 is involved in cell wall integrity, lipid metabolism, and virulence in Fusarium graminearum.

Authors:  Jinhua Jiang; Yingzi Yun; Qianqian Yang; Won-Bo Shim; Zhengyi Wang; Zhonghua Ma
Journal:  PLoS One       Date:  2011-09-28       Impact factor: 3.240

4.  The phosphatase Ptc6 is involved in virulence and MAPK signalling in Fusarium oxysporum.

Authors:  Juan Carlos Nunez-Rodriguez; Carmen Ruiz-Roldán; Pedro Lemos; Sergio Membrives; Concepcion Hera
Journal:  Mol Plant Pathol       Date:  2019-12-05       Impact factor: 5.663

5.  GlPP2C1 Silencing Increases the Content of Ganodermalingzhi Polysaccharide (GL-PS) and Enhances Slt2 Phosphorylation.

Authors:  Zi Wang; Ju-Hong Chen; Ling-Shuai Wang; Juan Ding; Ming-Wen Zhao; Rui Liu
Journal:  J Fungi (Basel)       Date:  2022-09-10

Review 6.  Regulatory roles of phosphorylation in model and pathogenic fungi.

Authors:  Mohammad T Albataineh; David Kadosh
Journal:  Med Mycol       Date:  2015-12-24       Impact factor: 4.076
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.