Literature DB >> 20446668

Synthesis of (+/-)-eusynstyelamide A.

Olga V Barykina1, Barry B Snider.   

Abstract

The synthesis of (+/-)-eusynstyelamide A has been accomplished in six steps in 13% overall yield from 6-bromoindole, methyl glycidate, and Boc-protected agmatine. If oxygen is carefully excluded from the reaction, the key NaOH-catalyzed aldol dimerization of the alpha-ketoamide proceeded efficiently to give Boc-protected eusynstyelamide A.

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Year:  2010        PMID： 20446668      PMCID： PMC2878381          DOI： 10.1021/ol100896n

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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