Literature DB >> 2044594

Maternal vegan diet causing a serious infantile neurological disorder due to vitamin B12 deficiency.

T Kühne1, R Bubl, R Baumgartner.   

Abstract

We present a 9-month-old exclusively breast-fed baby of a strict vegetarian mother who had excluded all animal proteins from her diet. The patient's symptoms included dystrophy, weakness, muscular atrophy, loss of tendon reflexes, psychomotor regression and haematological abnormalities. Biochemical investigations revealed severe methylmalonic aciduria and homocystinuria in the patient, slight methylmalonic aciduria in the mother and low concentrations of serum vitamin B12 in both patient and mother.

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Year:  1991        PMID： 2044594     DOI： 10.1007/bf01963568

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  15 in total

1.  Vitamin-B12 deficiency in pregnancy and the puerperium.

Authors:  S J BAKER; E JACOB; K T RAJAN; S P SWAMINATHAN
Journal:  Br Med J       Date:  1962-06-16

2.  Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.

Authors:  S P Stabler; P D Marcell; E R Podell; R H Allen; D G Savage; J Lindenbaum
Journal:  J Clin Invest       Date:  1988-02       Impact factor: 14.808

Review 3.  Nutritional vitamin B12 deficiency in infancy: three case reports and a review of the literature.

Authors:  J J Doyle; A M Langevin; A Zipursky
Journal:  Pediatr Hematol Oncol       Date:  1989       Impact factor: 1.969

4.  Megaloblastic anaemia in one of monozygous twins breast fed by their vegetarian mother.

Authors:  R C Gambon; M J Lentze; E Rossi
Journal:  Eur J Pediatr       Date:  1986-12       Impact factor: 3.183

5.  Fatty acid composition of myelin isolated from the brain of a patient with cellular deficiency of co-enzyme forms of vitamin B12.

Authors:  R B Ramsey; T Scott; N L Banik
Journal:  J Neurol Sci       Date:  1977-11       Impact factor: 3.181

6.  The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia.

Authors:  J M Scott; D G Weir
Journal:  Lancet       Date:  1981-08-15       Impact factor: 79.321

7.  Congenital defect in intracellular cobalamin metabolism resulting in homocysteinuria and methylmalonic aciduria. I. Case report and histopathology.

Authors:  E R Baumgartner; H Wick; R Maurer; N Egli; B Steinmann
Journal:  Helv Paediatr Acta       Date:  1979

8.  A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin B12-deficient breast-fed infant of a strict vegetarian.

Authors:  M C Higginbottom; L Sweetman; W L Nyhan
Journal:  N Engl J Med       Date:  1978-08-17       Impact factor: 91.245

9.  Assay of methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas chromatography-mass spectrometry.

Authors:  S P Stabler; P D Marcell; E R Podell; R H Allen; J Lindenbaum
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808

10.  Brain damage in infancy and dietary vitamin B12 deficiency.

Authors:  M C Wighton; J I Manson; I Speed; E Robertson; E Chapman
Journal:  Med J Aust       Date:  1979-07-14       Impact factor: 7.738
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  14 in total

Review 1.  Cobalamin status in children.

Authors:  Anne-Lise Bjørke-Monsen; Per Magne Ueland
Journal:  J Inherit Metab Dis       Date:  2010-05-27       Impact factor: 4.982

Review 2.  Persistence of neurological damage induced by dietary vitamin B-12 deficiency in infancy.

Authors:  U von Schenck; C Bender-Götze; B Koletzko
Journal:  Arch Dis Child       Date:  1997-08       Impact factor: 3.791

Review 3.  Markers of Maternal and Neonatal Cobalamin Status and Risk Assessment of Neurodevelopmental Disorders in Infants.

Authors:  Umesh Kapil; Sadhana Joshi
Journal:  Indian J Pediatr       Date:  2018-05-03       Impact factor: 1.967

Review 4.  Vegetarian diets in children: a systematic review.

Authors:  S Schürmann; M Kersting; U Alexy
Journal:  Eur J Nutr       Date:  2017-03-15       Impact factor: 5.614

5.  [6S]-5-Methyltetrahydrofolate enhances folate status in rats fed growing-up milk.

Authors:  Darío Pérez-Conesa; Juan Francisco Haro-Vicente; Fernando Romero Braquehais; Gaspar Ros
Journal:  Eur J Nutr       Date:  2009-04-23       Impact factor: 5.614

Review 6.  Effects of vitamin B12 and folate deficiency on brain development in children.

Authors:  Maureen M Black
Journal:  Food Nutr Bull       Date:  2008-06       Impact factor: 2.069

Review 7.  Severe encephalopathy with epilepsy in an infant caused by subclinical maternal pernicious anaemia: case report and review of the literature.

Authors:  G Christoph Korenke; Donald H Hunneman; Stefan Eber; Folker Hanefeld
Journal:  Eur J Pediatr       Date:  2004-02-05       Impact factor: 3.183

8.  Risks of alternative nutrition in infancy: a case report of severe iodine and carnitine deficiency.

Authors:  C Kanaka; B Schütz; K A Zuppinger
Journal:  Eur J Pediatr       Date:  1992-10       Impact factor: 3.183

9.  Growth retardation, general hypotonia, and loss of acquired neuromotor skills in the infants of mothers with cobalamin deficiency and the possible role of succinyl-CoA and glycine in the pathogenesis.

Authors:  Zafer Bicakci
Journal:  Medicine (Baltimore)       Date:  2015-03       Impact factor: 1.889

10.  High incidence of low vitamin B12 levels in Estonian newborns.

Authors:  Karit Reinson; Kadi Künnapas; Annika Kriisa; Mari-Anne Vals; Kai Muru; Katrin Õunap
Journal:  Mol Genet Metab Rep       Date:  2018-01-11
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