PURPOSE OF REVIEW: To analyze the current status of living donor intestinal transplantation (LDIT) as a treatment option for intestinal failure. RECENT FINDINGS: Long-term outcomes from LDIT and combined living donor intestinal/liver transplantation (CLDILT) are comparable with those from transplantation using deceased donors. In certain life-threatening situations, especially in pediatric patients, this strategy may offer potential advantages. SUMMARY: According United Network for Organ Sharing (UNOS) data children with intestinal failure affected by liver disease secondary to parenteral nutrition have the highest mortality on a waiting list compared with all candidates for solid organ transplantation. Elective nature of CLDILT offers multiple advantages for this patient population. LDIT also could be life-saving option for patients with intestinal failure who run out of venous access. Optimal timing, short ischemia time and good human leukocyte antigen (HLA) matching may contribute to lower postoperative complications. Current literature suggests that living intestinal donors experience very low morbidity and high level of satisfaction.
PURPOSE OF REVIEW: To analyze the current status of living donor intestinal transplantation (LDIT) as a treatment option for intestinal failure. RECENT FINDINGS: Long-term outcomes from LDIT and combined living donor intestinal/liver transplantation (CLDILT) are comparable with those from transplantation using deceased donors. In certain life-threatening situations, especially in pediatric patients, this strategy may offer potential advantages. SUMMARY: According United Network for Organ Sharing (UNOS) data children with intestinal failure affected by liver disease secondary to parenteral nutrition have the highest mortality on a waiting list compared with all candidates for solid organ transplantation. Elective nature of CLDILT offers multiple advantages for this patient population. LDIT also could be life-saving option for patients with intestinal failure who run out of venous access. Optimal timing, short ischemia time and good human leukocyte antigen (HLA) matching may contribute to lower postoperative complications. Current literature suggests that living intestinal donors experience very low morbidity and high level of satisfaction.
Authors: S Weih; M Kessler; H Fonouni; M Golriz; M Hafezi; A Mehrabi; S Holland-Cunz Journal: Langenbecks Arch Surg Date: 2011-11-22 Impact factor: 3.445
Authors: Raquel Garcia-Roca; Ivo G Tzvetanov; Hoonbae Jeon; Elisabeth Hetterman; Jose Oberholzer; Enrico Benedetti Journal: World J Gastrointest Surg Date: 2016-01-27
Authors: Yang Yang; Hong Li Song; Wen Zhang; Ben Juan Wu; Nan Nan Fu; Chong Dong; Zhong Yang Shen Journal: Stem Cell Res Ther Date: 2016-11-20 Impact factor: 6.832