Harry Sokol1, Philippe Seksik. 1. Gastroenterology and Nutrition Department, Saint Antoine Hospital, Université Pierre et Marie Curie, Paris VI, AP-HP, Paris, France. sokol_harry@yahoo.fr
Abstract
PURPOSE OF REVIEW: The aim of this review is to report recent findings regarding the role of the gut microbiota in inflammatory bowel disease pathogenesis. RECENT FINDINGS: After a description of the current knowledge on inflammatory bowel diseases-associated dysbiosis, we will focus on the recent functional studies that analyzed the cross relationship between the gut microbiota and the host. SUMMARY: Recently published studies have provided an insight into the altered dialog between the intestinal microbiota and the host leading to gut inflammation. Further investigation will allow identifying new therapeutic targets either in the microbiota or the host.
PURPOSE OF REVIEW: The aim of this review is to report recent findings regarding the role of the gut microbiota in inflammatory bowel disease pathogenesis. RECENT FINDINGS: After a description of the current knowledge on inflammatory bowel diseases-associated dysbiosis, we will focus on the recent functional studies that analyzed the cross relationship between the gut microbiota and the host. SUMMARY: Recently published studies have provided an insight into the altered dialog between the intestinal microbiota and the host leading to gut inflammation. Further investigation will allow identifying new therapeutic targets either in the microbiota or the host.
Authors: Claire B Larmonier; Daniel Laubitz; Faihza M Hill; Kareem W Shehab; Leszek Lipinski; Monica T Midura-Kiela; Rita-Marie T McFadden; Rajalakshmy Ramalingam; Kareem A Hassan; Marcin Golebiewski; David G Besselsen; Fayez K Ghishan; Pawel R Kiela Journal: Am J Physiol Gastrointest Liver Physiol Date: 2013-09-12 Impact factor: 4.052
Authors: Giuseppina Liguori; Bruno Lamas; Mathias L Richard; Giovanni Brandi; Gregory da Costa; Thomas W Hoffmann; Massimo Pierluigi Di Simone; Carlo Calabrese; Gilberto Poggioli; Philippe Langella; Massimo Campieri; Harry Sokol Journal: J Crohns Colitis Date: 2015-11-15 Impact factor: 9.071