OBJECTIVE: The purpose of this study was to determine if folic acid supplementation improves endothelial vascular function (brachial artery flow-mediated dilation; FMD) in amenorrheic runners. DESIGN: Prospective cross-sectional study. SETTING: Academic medical center in the Midwest. PARTICIPANTS: Ten amenorrheic and 10 eumenorrheic women runners from the community volunteered for this study. INTERVENTIONS: Each participant was treated with folic acid (10 mg/d) for 4 weeks. MAIN OUTCOME MEASURES: Brachial artery FMD was measured before and after folic acid supplementation with standard techniques. RESULTS: The brachial artery FMD response to reactive hyperemia improved after folic acid supplementation in amenorrheic women (3.0% +/- 2.3% vs. 7.7% +/- 4.5%; P = 0.02). In the eumenorrheic control group, there was no change in brachial artery FMD (6.7% +/- 2.0% vs. 5.9% +/- 2.6%; P = 0.52). CONCLUSIONS: This study demonstrates that brachial artery FMD, an indicator of vascular endothelial function, improves in amenorrheic female runners after short-term supplementation with folic acid.
OBJECTIVE: The purpose of this study was to determine if folic acid supplementation improves endothelial vascular function (brachial artery flow-mediated dilation; FMD) in amenorrheic runners. DESIGN: Prospective cross-sectional study. SETTING: Academic medical center in the Midwest. PARTICIPANTS: Ten amenorrheic and 10 eumenorrheic women runners from the community volunteered for this study. INTERVENTIONS: Each participant was treated with folic acid (10 mg/d) for 4 weeks. MAIN OUTCOME MEASURES: Brachial artery FMD was measured before and after folic acid supplementation with standard techniques. RESULTS: The brachial artery FMD response to reactive hyperemia improved after folic acid supplementation in amenorrheic women (3.0% +/- 2.3% vs. 7.7% +/- 4.5%; P = 0.02). In the eumenorrheic control group, there was no change in brachial artery FMD (6.7% +/- 2.0% vs. 5.9% +/- 2.6%; P = 0.52). CONCLUSIONS: This study demonstrates that brachial artery FMD, an indicator of vascular endothelial function, improves in amenorrheic female runners after short-term supplementation with folic acid.
Authors: Steven A Romero; Daniel Gagnon; Amy N Adams; Gilbert Moralez; Ken Kouda; Manall F Jaffery; Matthew N Cramer; Craig G Crandall Journal: Am J Physiol Heart Circ Physiol Date: 2017-06-30 Impact factor: 4.733
Authors: Anne Z Hoch; Paula Papanek; Aniko Szabo; Michael E Widlansky; Jane E Schimke; David D Gutterman Journal: Clin J Sport Med Date: 2011-03 Impact factor: 3.638