Literature DB >> 20445061

Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.

Ahmad Jowaed1, Ina Schmitt, Oliver Kaut, Ullrich Wüllner.   

Abstract

Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD), and increased SNCA gene dosage results in a parkinsonian syndrome in affected families. We found that methylation of human SNCA intron 1 decreased gene expression, while inhibition of DNA methylation activated SNCA expression. Methylation of SNCA intron 1 was reduced in DNA from sporadic PD patients' substantia nigra, putamen, and cortex, pointing toward a yet unappreciated epigenetic regulation of SNCA expression in PD.

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Year:  2010        PMID： 20445061      PMCID： PMC6632710          DOI： 10.1523/JNEUROSCI.6119-09.2010

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  23 in total

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2.  alpha-Synuclein locus triplication causes Parkinson's disease.

Authors:  A B Singleton; M Farrer; J Johnson; A Singleton; S Hague; J Kachergus; M Hulihan; T Peuralinna; A Dutra; R Nussbaum; S Lincoln; A Crawley; M Hanson; D Maraganore; C Adler; M R Cookson; M Muenter; M Baptista; D Miller; J Blancato; J Hardy; K Gwinn-Hardy
Journal:  Science       Date:  2003-10-31       Impact factor: 47.728

3.  Methylenetetrahydrofolate reductase in Parkinson's disease.

Authors:  Ullrich Wüllner; Heike Kölsch; Michael Linnebank
Journal:  Ann Neurol       Date:  2005-12       Impact factor: 10.422

4.  Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients.

Authors:  Ornit Chiba-Falek; Grisel J Lopez; Robert L Nussbaum
Journal:  Mov Disord       Date:  2006-10       Impact factor: 10.338

Review 5.  Phenotypic plasticity and the epigenetics of human disease.

Authors:  Andrew P Feinberg
Journal:  Nature       Date:  2007-05-24       Impact factor: 49.962

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Journal:  JAMA       Date:  2006-08-09       Impact factor: 56.272

7.  Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease.

Authors:  Ikuko Mizuta; Wataru Satake; Yuko Nakabayashi; Chiyomi Ito; Satoko Suzuki; Yoshio Momose; Yoshitaka Nagai; Akira Oka; Hidetoshi Inoko; Jiro Fukae; Yuko Saito; Motoji Sawabe; Shigeo Murayama; Mitsutoshi Yamamoto; Nobutaka Hattori; Miho Murata; Tatsushi Toda
Journal:  Hum Mol Genet       Date:  2006-02-24       Impact factor: 6.150

8.  Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus.

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Journal:  FASEB J       Date:  2006-12-13       Impact factor: 5.191

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Journal:  J Alzheimers Dis       Date:  2001-10       Impact factor: 4.472
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  139 in total

Review 1.  Recent advances in the genetics of Parkinson's disease.

Authors:  Ian Martin; Valina L Dawson; Ted M Dawson
Journal:  Annu Rev Genomics Hum Genet       Date:  2011       Impact factor: 8.929

2.  Next-generation sequencing reveals regional differences of the α-synuclein methylation state independent of Lewy body disease.

Authors:  L de Boni; S Tierling; S Roeber; J Walter; A Giese; Hans A Kretzschmar
Journal:  Neuromolecular Med       Date:  2011-11-01       Impact factor: 3.843

Review 3.  DNA modifications and neurological disorders.

Authors:  Yi-Lan Weng; Ran An; Jaehoon Shin; Hongjun Song; Guo-li Ming
Journal:  Neurotherapeutics       Date:  2013-10       Impact factor: 7.620

Review 4.  Epigenetic regulation in Parkinson's disease.

Authors:  Catherine Labbé; Oswaldo Lorenzo-Betancor; Owen A Ross
Journal:  Acta Neuropathol       Date:  2016-06-29       Impact factor: 17.088

5.  DNA Methyltransferase 1 Is Dysregulated in Parkinson's Disease via Mediation of miR-17.

Authors:  Hong-Qiu Zhang; Jian-Yong Wang; Zhao-Feng Li; Lei Cui; Shi-Shi Huang; Lan-Bing Zhu; Yue Sun; Rui Yang; Hui-Hui Fan; Xiong Zhang; Jian-Hong Zhu
Journal:  Mol Neurobiol       Date:  2021-01-22       Impact factor: 5.590

6.  Spatial distribution of 5-hydroxymethyl cytosine in rat brain and temporal distribution in striatum.

Authors:  Tingting Zheng; Qing Lv; Xiaoguang Lei; Xinzhen Yin; Baorong Zhang
Journal:  Neurochem Res       Date:  2015-02-03       Impact factor: 3.996

7.  β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.

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Journal:  Science       Date:  2017-09-01       Impact factor: 47.728

8.  Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease.

Authors:  Izaskun Villar-Menéndez; Marta Blanch; Shiraz Tyebji; Thais Pereira-Veiga; José Luis Albasanz; Mairena Martín; Isidre Ferrer; Esther Pérez-Navarro; Marta Barrachina
Journal:  Neuromolecular Med       Date:  2013-02-06       Impact factor: 3.843

9.  APOE DNA methylation is altered in Lewy body dementia.

Authors:  Jessica Tulloch; Lesley Leong; Sunny Chen; C Dirk Keene; Steven P Millard; Andrew Shutes-David; Oscar L Lopez; Julia Kofler; Jeffrey A Kaye; Randy Woltjer; Peter T Nelson; Janna H Neltner; Gregory A Jicha; Douglas Galasko; Eliezer Masliah; James B Leverenz; Chang-En Yu; Debby Tsuang
Journal:  Alzheimers Dement       Date:  2018-03-12       Impact factor: 21.566

10.  Epigenetics-Based Therapeutics for Neurodegenerative Disorders.

Authors:  Zihui Xu; He Li; Peng Jin
Journal:  Curr Transl Geriatr Exp Gerontol Rep       Date:  2012-09-18
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