| Literature DB >> 20444602 |
Darby Schmidt1, Abigail Smenton, Subharekha Raghavan, Hong Shen, Fa-Xiang Ding, Ester Carballo-Jane, Silvi Luell, Tanya Ciecko, Tom G Holt, Michael Wolff, Andrew Taggart, Larissa Wilsie, Mihajlo Krsmanovic, Ning Ren, Daniel Blom, Kang Cheng, Peggy E McCann, M Gerard Waters, James Tata, Steven Colletti.
Abstract
Niacin is an effective drug for raising HDL cholesterol. However, niacin must be taken in large doses and significant side effects are often observed, including facial flushing, loss of glucose tolerance, and liver toxicity. An anthranilic acid was identified as an agonist of the niacin receptor. In order to improve efficacy and provide structural diversity, replacements for the anthranilic acid were investigated and several compounds with improved properties were identified. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20444602 DOI： 10.1016/j.bmcl.2010.04.001
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823