Literature DB >> 20444497

Vacuum-based preservation of surgical specimens: an environmentally-safe step towards a formalin-free hospital.

Cinzia Di Novi1, Davide Minniti, Silvana Barbaro, Maria Gabriella Zampirolo, Antonio Cimino, Gianni Bussolati.   

Abstract

Formalin as a fixative has no practical substitutes, but is toxic and potentially carcinogenic, so caution of its use in hospitals and elsewhere is mandatory. In our hospital, preservation of surgical specimens into formalin to be transferred to pathology labs was replaced by under-vacuum sealing (UVS) tissues into plastic bags and preservation at 4 degrees C until transfer. Data analysis showed UVS processing to be superior in terms of staff satisfaction and of gross anatomic preservation; no problems in terms of technical feasibility or histopathologic preservation were encountered. Formalin was confined to pathology labs while its use on hospital premises was vastly reduced.

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Year:  2010        PMID: 20444497     DOI: 10.1016/j.scitotenv.2010.04.022

Source DB:  PubMed          Journal:  Sci Total Environ        ISSN: 0048-9697            Impact factor:   7.963


  9 in total

1.  Towards a formalin-free hospital. Levels of 15-F2t-isoprostane and malondialdehyde to monitor exposure to formaldehyde in nurses from operating theatres.

Authors:  Valeria Bellisario; Giulio Mengozzi; Elena Grignani; Massimiliano Bugiani; Anna Sapino; Gianni Bussolati; Roberto Bono
Journal:  Toxicol Res (Camb)       Date:  2016-04-26       Impact factor: 3.524

2.  Pathological Diagnosis, Work-Up and Reporting of Breast Cancer 1st Central-Eastern European Professional Consensus Statement on Breast Cancer.

Authors:  Gábor Cserni; Monika Francz; Balázs Járay; Endre Kálmán; Ilona Kovács; Tibor Krenács; Erika Tóth; Nóra Udvarhelyi; László Vass; András Vörös; Ana Krivokuca; Karol Kajo; Katarína Kajová Macháleková; Janina Kulka
Journal:  Pathol Oncol Res       Date:  2022-06-27       Impact factor: 2.874

3.  Safe transportation of formalin-fixed liquid-free pathology specimens.

Authors:  J Metovic; L Bertero; C Musuraca; F Veneziano; L Annaratone; S Mariani; P Cassoni; G Bussolati; Mauro Papotti
Journal:  Virchows Arch       Date:  2018-06-02       Impact factor: 4.064

4.  Efficient stem cell isolation from under vacuum preserved tissue samples.

Authors:  Aldo Moggio; Giuseppe D'Armento; Benedetta Bussolati
Journal:  Organogenesis       Date:  2012-07-01       Impact factor: 2.500

5.  Formalin fixation at low temperature better preserves nucleic acid integrity.

Authors:  Gianni Bussolati; Laura Annaratone; Enzo Medico; Giuseppe D'Armento; Anna Sapino
Journal:  PLoS One       Date:  2011-06-15       Impact factor: 3.240

6.  Critical roles of specimen type and temperature before and during fixation in the detection of phosphoproteins in breast cancer tissues.

Authors:  Sibylle Gündisch; Laura Annaratone; Christian Beese; Enken Drecol; Caterina Marchiò; Elena Quaglino; Anna Sapino; Karl-Friedrich Becker; Gianni Bussolati
Journal:  Lab Invest       Date:  2015-03-02       Impact factor: 5.662

7.  Occupational exposure to airborne formaldehyde in hospital: setting an automatic sampling system, comparing different monitoring methods and applying them to assess exposure.

Authors:  Nicola Mucci; Stefano Dugheri; Venerando Rapisarda; Marcello Campagna; Giacomo Garzaro; Andrea Farioli; Giovanni Cappelli; Giulio Arcangeli
Journal:  Med Lav       Date:  2019-12-17       Impact factor: 1.275

8.  A collection of primary tissue cultures of tumors from vacuum packed and cooled surgical specimens: a feasibility study.

Authors:  Laura Annaratone; Caterina Marchiò; Rosalia Russo; Luigi Ciardo; Sandra Milena Rondon-Lagos; Margherita Goia; Maria Stella Scalzo; Stefania Bolla; Isabella Castellano; Ludovica Verdun di Cantogno; Gianni Bussolati; Anna Sapino
Journal:  PLoS One       Date:  2013-09-30       Impact factor: 3.240

9.  A tissue quality index: an intrinsic control for measurement of effects of preanalytical variables on FFPE tissue.

Authors:  Veronique M Neumeister; Fabio Parisi; Allison M England; Summar Siddiqui; Valsamo Anagnostou; Elizabeth Zarrella; Maria Vassilakopolou; Yalai Bai; Sasha Saylor; Anna Sapino; Yuval Kluger; David G Hicks; Gianni Bussolati; Stephanie Kwei; David L Rimm
Journal:  Lab Invest       Date:  2014-02-17       Impact factor: 5.662

  9 in total

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