BACKGROUND: New biologic therapies are available for moderate to severe psoriasis. OBJECTIVE: To determine the most cost-effective sequence of biologic treatments. METHODS: Through modeling of the clinical pathway of biologic agents, adalimumab, alefacept, efalizumab, etanercept, and infliximab, the costs and benefits (quality-adjusted life-years [QALYs]) were determined. A decision rule determined the optimal treatment sequence comparing costs and QALYs. RESULTS: While infliximab was found to provide the most incremental QALY and etanercept was found to be the least costly, on balance, the incremental cost-effectiveness ratio of adalimumab was the most favorable (ICER = $544/QALY). Consequently, the optimal sequence would begin with adalimumab and be followed by etanercept, infliximab, efalizumab, and alefacept, respectively. The limitations of this study are that evidence was based on indirect comparisons of biologic effectiveness, and toxicities were not included in the model. CONCLUSIONS: In consideration of cost-effectiveness in prescribing biologics for moderate to severe psoriasis, the optimal sequence would begin with adalimumab.
BACKGROUND: New biologic therapies are available for moderate to severe psoriasis. OBJECTIVE: To determine the most cost-effective sequence of biologic treatments. METHODS: Through modeling of the clinical pathway of biologic agents, adalimumab, alefacept, efalizumab, etanercept, and infliximab, the costs and benefits (quality-adjusted life-years [QALYs]) were determined. A decision rule determined the optimal treatment sequence comparing costs and QALYs. RESULTS: While infliximab was found to provide the most incremental QALY and etanercept was found to be the least costly, on balance, the incremental cost-effectiveness ratio of adalimumab was the most favorable (ICER = $544/QALY). Consequently, the optimal sequence would begin with adalimumab and be followed by etanercept, infliximab, efalizumab, and alefacept, respectively. The limitations of this study are that evidence was based on indirect comparisons of biologic effectiveness, and toxicities were not included in the model. CONCLUSIONS: In consideration of cost-effectiveness in prescribing biologics for moderate to severe psoriasis, the optimal sequence would begin with adalimumab.
Authors: Andreas Kuznik; Gaëlle Bégo-Le-Bagousse; Laurent Eckert; Abhijit Gadkari; Eric Simpson; Christopher N Graham; LaStella Miles; Vera Mastey; Puneet Mahajan; Sean D Sullivan Journal: Dermatol Ther (Heidelb) Date: 2017-09-20