BACKGROUND/AIMS: Vascular dementia (VaD) is the second common cause of dementia after Alzheimer's disease (AD) in later life. The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism as a risk factor in VaD has been suggested, but direct evidence from genetic association studies remain inconclusive. We performed a meta-analysis pooling data from all relevant studies in order to determine the effect of the MTHFR C677T polymorphism on VaD. METHODS: We applied a random-effects or fixed-effects model to combine odds ratio (OR) and 95% confidence intervals (95%CI). Q statistic was used to evaluate the homogeneity, and Egger's test and Funnel plot were used to assess publication bias. RESULTS: A total of 11 studies, comprising 672 cases and 1038 controls, were included worldwide. Publication bias was not observed. This meta-analysis demonstrated that the MTHFR T allele or TT genotype had an increased risk for VaD in general populations (OR, 95%CI: 1.27, 1.01-1.59; 1.41, 1.06-1.88, respectively), and a significant association was found in allele contrast, recessive, and dominant model in Asian populations, but not in Caucasian populations. CONCLUSION: The MTHFR C677T polymorphism (mainly TT genotype) is associated with developing VaD in general populations or Asian populations. Copyright 2010 Elsevier B.V. All rights reserved.
BACKGROUND/AIMS: Vascular dementia (VaD) is the second common cause of dementia after Alzheimer's disease (AD) in later life. The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism as a risk factor in VaD has been suggested, but direct evidence from genetic association studies remain inconclusive. We performed a meta-analysis pooling data from all relevant studies in order to determine the effect of the MTHFRC677T polymorphism on VaD. METHODS: We applied a random-effects or fixed-effects model to combine odds ratio (OR) and 95% confidence intervals (95%CI). Q statistic was used to evaluate the homogeneity, and Egger's test and Funnel plot were used to assess publication bias. RESULTS: A total of 11 studies, comprising 672 cases and 1038 controls, were included worldwide. Publication bias was not observed. This meta-analysis demonstrated that the MTHFR T allele or TT genotype had an increased risk for VaD in general populations (OR, 95%CI: 1.27, 1.01-1.59; 1.41, 1.06-1.88, respectively), and a significant association was found in allele contrast, recessive, and dominant model in Asian populations, but not in Caucasian populations. CONCLUSION: The MTHFRC677T polymorphism (mainly TT genotype) is associated with developing VaD in general populations or Asian populations. Copyright 2010 Elsevier B.V. All rights reserved.
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Authors: Adrian L Oblak; Kevin P Kotredes; Ravi S Pandey; Alaina M Reagan; Cynthia Ingraham; Bridget Perkins; Christopher Lloyd; Deborah Baker; Peter B Lin; Disha M Soni; Andy P Tsai; Scott A Persohn; Amanda A Bedwell; Kierra Eldridge; Rachael Speedy; Jill A Meyer; Johnathan S Peters; Lucas L Figueiredo; Michael Sasner; Paul R Territo; Stacey J Sukoff Rizzo; Gregory W Carter; Bruce T Lamb; Gareth R Howell Journal: Front Aging Neurosci Date: 2022-06-24 Impact factor: 5.702