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Literature DB >> 20441735

A multiscale model of venous thrombus formation with surface-mediated control of blood coagulation cascade.

Zhiliang Xu¹, Joshua Lioi, Jian Mu, Malgorzata M Kamocka, Xiaomin Liu, Danny Z Chen, Elliot D Rosen, Mark Alber.

Abstract

A combination of the extended multiscale model, new image processing algorithms, and biological experiments is used for studying the role of Factor VII (FVII) in venous thrombus formation. A detailed submodel of the tissue factor pathway of blood coagulation is introduced within the framework of the multiscale model to provide a detailed description of coagulation cascade. Surface reactions of the extrinsic coagulation pathway on membranes of platelets are studied under different flow conditions. It is shown that low levels of FVII in blood result in a significant delay in thrombin production, demonstrating that FVII plays an active role in promoting thrombus development at an early stage. Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Entities: Disease Gene

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Year: 2010 PMID： 20441735 PMCID： PMC2862154 DOI： 10.1016/j.bpj.2009.12.4331

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

24 in total

1. Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo.

Authors: Sabine Grüner; Miroslava Prostredna; Valerie Schulte; Thomas Krieg; Beate Eckes; Cord Brakebusch; Bernhard Nieswandt
Journal: Blood Date: 2003-07-31 Impact factor: 22.113

Review 2. The tissue factor pathway of blood coagulation.

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Journal: Semin Hematol Date: 1992-07 Impact factor: 3.851

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Authors: M P McGee; T Chou
Journal: J Biol Chem Date: 2000-12-06 Impact factor: 5.157

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Authors: B Blombäck; K Carlsson; B Hessel; A Liljeborg; R Procyk; N Aslund
Journal: Biochim Biophys Acta Date: 1989-07-27

6. Surface-mediated control of blood coagulation: the role of binding site densities and platelet deposition.

Authors: A L Kuharsky; A L Fogelson
Journal: Biophys J Date: 2001-03 Impact factor: 4.033

7. A model for the stoichiometric regulation of blood coagulation.

Authors: Matthew F Hockin; Kenneth C Jones; Stephen J Everse; Kenneth G Mann
Journal: J Biol Chem Date: 2002-03-13 Impact factor: 5.157

8. A mathematical model of lipid-mediated thrombin generation.

Authors: Sharene D Bungay; Patricia A Gentry; Rodney D Gentry
Journal: Math Med Biol Date: 2003-03 Impact factor: 1.854

Review 9. The blood coagulation cascade.

Authors: Monica Schenone; Barbara C Furie; Bruce Furie
Journal: Curr Opin Hematol Date: 2004-07 Impact factor: 3.284

Review 10. Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation.

Authors: Marlies Van de Wouwer; Désiré Collen; Edward M Conway
Journal: Arterioscler Thromb Vasc Biol Date: 2004-06-03 Impact factor: 8.311

47 in total

1. Is there value in kinetic modeling of thrombin generation? Yes.

Authors: K G Mann
Journal: J Thromb Haemost Date: 2012-08 Impact factor: 5.824

2. A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity.

Authors: Timothy J Stalker; John D Welsh; Maurizio Tomaiuolo; Jie Wu; Thomas V Colace; Scott L Diamond; Lawrence F Brass
Journal: Blood Date: 2014-06-20 Impact factor: 22.113

A multiscale model of venous thrombus formation with surface-mediated control of blood coagulation cascade.

1. Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo.

Review 2. The tissue factor pathway of blood coagulation.

Review 3. Hereditary protein C deficiency: a review of the genetics, clinical presentation, diagnosis and treatment.

4. Surface-dependent coagulation enzymes. Flow kinetics of factor Xa generation on live cell membranes.

5. Native fibrin gel networks observed by 3D microscopy, permeation and turbidity.

6. Surface-mediated control of blood coagulation: the role of binding site densities and platelet deposition.

7. A model for the stoichiometric regulation of blood coagulation.

8. A mathematical model of lipid-mediated thrombin generation.

Review 9. The blood coagulation cascade.

Review 10. Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation.

1. Is there value in kinetic modeling of thrombin generation? Yes.

2. A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity.

3. Simulation of aggregating particles in complex flows by the lattice kinetic Monte Carlo method.

4. Modelling platelet-blood flow interaction using the subcellular element Langevin method.

5. Modelling of platelet-fibrin clot formation in flow with a DPD-PDE method.

6. Elastic behavior and platelet retraction in low- and high-density fibrin gels.

7. The hydraulic permeability of blood clots as a function of fibrin and platelet density.

Review 8. Systems biology of platelet-vessel wall interactions.

9. Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood.

Review 10. Biochemomechanics of intraluminal thrombus in abdominal aortic aneurysms.