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Literature DB >> 20441202

Pattern-based recognition for determination of enantiomeric excess, using chiral auxiliary induced chemical shift perturbation NMR.

Xinxiang Lei¹, Lu Liu, Xiaojing Chen, Xiaochun Yu, Lisheng Ding, Anjiang Zhang.

Abstract

A protocol for the determination of enantiomeric excess of chiral carboxylic acid, using the subtle frequency shifts (chemical shift perturbation) in NMR spectra induced by chiral auxiliary, is described. The spectra were analyzed with two pattern recognition protocols. Principal component analysis demonstrated good enantioselective separation of the analytes, and partial least-squares was used to analyze ee values of unknown samples.

Entities: Chemical

Mesh：

Substances：
Carboxylic Acids

Year: 2010 PMID： 20441202 DOI： 10.1021/ol100773s

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

3 in total

1. Chiral discrimination of α-hydroxy acids and N-Ts-α-amino acids induced by tetraaza macrocyclic chiral solvating agents by using ¹H NMR spectroscopy.

Authors: Caixia Lv; Lei Feng; Hongmei Zhao; Guo Wang; Pericles Stavropoulos; Lin Ai
Journal: Org Biomol Chem Date: 2017-01-27 Impact factor: 3.876

2. Efficient Enantiodifferentiation of Carboxylic Acids Using BINOL-Based Amino Alcohol as a Chiral NMR Solvating Agent.

Authors: Gaowei Li; Minshan Ma; Guifang Wang; Xiaojuan Wang; Xinxiang Lei
Journal: Front Chem Date: 2020-05-04 Impact factor: 5.221

3. Azaheterocyclic diphenylmethanol chiral solvating agents for the NMR chiral discrimination of alpha-substituted carboxylic acids.

Authors: Gao-Wei Li; Xiao-Juan Wang; Dan-Dan Cui; Yu-Fei Zhang; Rong-Yao Xu; Shuai-Hua Shi; Lan-Tao Liu; Min-Can Wang; Hong-Min Liu; Xin-Xiang Lei
Journal: RSC Adv Date: 2020-09-18 Impact factor: 4.036

3 in total

Pattern-based recognition for determination of enantiomeric excess, using chiral auxiliary induced chemical shift perturbation NMR.

1. Chiral discrimination of α-hydroxy acids and N-Ts-α-amino acids induced by tetraaza macrocyclic chiral solvating agents by using 1H NMR spectroscopy.

2. Efficient Enantiodifferentiation of Carboxylic Acids Using BINOL-Based Amino Alcohol as a Chiral NMR Solvating Agent.

3. Azaheterocyclic diphenylmethanol chiral solvating agents for the NMR chiral discrimination of alpha-substituted carboxylic acids.

1. Chiral discrimination of α-hydroxy acids and N-Ts-α-amino acids induced by tetraaza macrocyclic chiral solvating agents by using ¹H NMR spectroscopy.