AIM: To investigate the association between peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene polymorphism 34 C>G and colorectal cancer (CRC), a meta-analysis review was performed in this report. METHODS: A systematic literature search and selection of eligible relevant studies were carried out. Nine independent studies with a total number of 4533 cases and 6483 controls were included in the meta-analysis on the association between polymorphism 34 C>G and CRC. RESULTS: There was no evidence for the association between PPAR-gamma 34 C>G and CRC if all of the subjects in the nine studies were included. However, CG + GG showed a marginally significant difference from CC (OR = 0.84, 95% CI: 0.69-1.01, P = 0.07) in random-effect model. Stratified meta-analysis indicated that PPAR-gamma 34 C>G was associated with colon cancer (OR = 0.8, 95% CI: 0.65-0.99, P = 0.04) in random-effect model, and the G allele decreased colon cancer risk. No significant association was observed between PPAR-gamma 34 C>G and rectal cancer. CONCLUSION: PPAR-gamma 34 C>G is associated with colon cancer risk, but not associated with CRC and rectal cancer risk.
AIM: To investigate the association between peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene polymorphism 34 C>G and colorectal cancer (CRC), a meta-analysis review was performed in this report. METHODS: A systematic literature search and selection of eligible relevant studies were carried out. Nine independent studies with a total number of 4533 cases and 6483 controls were included in the meta-analysis on the association between polymorphism 34 C>G and CRC. RESULTS: There was no evidence for the association between PPAR-gamma 34 C>G and CRC if all of the subjects in the nine studies were included. However, CG + GG showed a marginally significant difference from CC (OR = 0.84, 95% CI: 0.69-1.01, P = 0.07) in random-effect model. Stratified meta-analysis indicated that PPAR-gamma 34 C>G was associated with colon cancer (OR = 0.8, 95% CI: 0.65-0.99, P = 0.04) in random-effect model, and the G allele decreased colon cancer risk. No significant association was observed between PPAR-gamma 34 C>G and rectal cancer. CONCLUSION:PPAR-gamma 34 C>G is associated with colon cancer risk, but not associated with CRC and rectal cancer risk.
Authors: Ulla Vogel; Jane Christensen; Marianne Dybdahl; Søren Friis; Rikke D Hansen; Håkan Wallin; Bjørn A Nexø; Ole Raaschou-Nielsen; Paal S Andersen; Kim Overvad; Anne Tjønneland Journal: Mutat Res Date: 2007-04-27 Impact factor: 2.433
Authors: Meena K Sakharkar; Babita Shashni; Karun Sharma; Sarinder K Dhillon; Prabhakar R Ranjekar; Kishore R Sakharkar Journal: PPAR Res Date: 2013-02-03 Impact factor: 4.964
Authors: Ravindran Ankathil; Mohd Aminudin Mustapha; Ahmad Aizat Abdul Aziz; Siti Nurfatimah Mohd Shahpudin; Andee Dzulkarnaen Zakaria; Muhammad Radzi Abu Hassan; Kamarul Imran Musa Journal: Asian Pac J Cancer Prev Date: 2019-06-01