Literature DB >> 20440595

Nutrient regulation of enteroendocrine cellular activity linked to cholecystokinin gene expression and secretion.

K N Nilaweera1, L Giblin, R P Ross.   

Abstract

The hormone cholecystokinin is produced by the enteroendocrine I cells in the intestine, and it plays an important role in a number of physiological processes including digestion and food intake. Recent data suggest that cholecystokinin gene expression and protein secretion are regulated by macronutrients. The mechanism involves a change in intracellular levels of cAMP and Ca(+2), brought about by the activity of a number of nutrient-responsive G protein-coupled receptors, nutrient transporters, ion channels and intracellular enzymes. How these intracellular responses could lead to gene expression and protein secretion are discussed along with new directions for future investigation.

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Year:  2010        PMID： 20440595     DOI： 10.1007/s13105-010-0012-z

Source DB:  PubMed          Journal:  J Physiol Biochem        ISSN： 1138-7548            Impact factor:   4.158


  58 in total

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