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Literature DB >> 20440275

How antibiotics kill bacteria: from targets to networks.

Michael A Kohanski¹, Daniel J Dwyer, James J Collins.

Abstract

Antibiotic drug-target interactions, and their respective direct effects, are generally well characterized. By contrast, the bacterial responses to antibiotic drug treatments that contribute to cell death are not as well understood and have proven to be complex as they involve many genetic and biochemical pathways. In this Review, we discuss the multilayered effects of drug-target interactions, including the essential cellular processes that are inhibited by bactericidal antibiotics and the associated cellular response mechanisms that contribute to killing. We also discuss new insights into these mechanisms that have been revealed through the study of biological networks, and describe how these insights, together with related developments in synthetic biology, could be exploited to create new antibacterial therapies.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20440275 PMCID： PMC2896384 DOI： 10.1038/nrmicro2333

Source DB: PubMed Journal: Nat Rev Microbiol ISSN： 1740-1526 Impact factor: 60.633

138 in total

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Journal: Nat Struct Biol Date: 2000-02

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Journal: Nature Date: 2000-03-02 Impact factor: 49.962

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Journal: J Gen Microbiol Date: 1962-07

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Authors: R Novak; E Charpentier; J S Braun; E Tuomanen
Journal: Mol Cell Date: 2000-01 Impact factor: 17.970

6. Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis.

Authors: Michael A Kohanski; Mark A DePristo; James J Collins
Journal: Mol Cell Date: 2010-02-12 Impact factor: 17.970

7. Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase.

Authors: A Vazquez-Torres; Y Xu; J Jones-Carson; D W Holden; S M Lucia; M C Dinauer; P Mastroeni; F C Fang
Journal: Science Date: 2000-03-03 Impact factor: 47.728

8. Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli.

Authors: Bryan W Davies; Michael A Kohanski; Lyle A Simmons; Jonathan A Winkler; James J Collins; Graham C Walker
Journal: Mol Cell Date: 2009-12-11 Impact factor: 17.970

9. The Staphylococcus aureus lrgAB operon modulates murein hydrolase activity and penicillin tolerance.

Authors: K H Groicher; B A Firek; D F Fujimoto; K W Bayles
Journal: J Bacteriol Date: 2000-04 Impact factor: 3.490

10. Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death.

Authors: Xiuhong Wang; Xilin Zhao; Muhammad Malik; Karl Drlica
Journal: J Antimicrob Chemother Date: 2010-01-12 Impact factor: 5.790

480 in total

1. Genome-wide discovery of epistatic loci affecting antibiotic resistance in Neisseria gonorrhoeae using evolutionary couplings.

Authors: Benjamin Schubert; Rohan Maddamsetti; Jackson Nyman; Maha R Farhat; Debora S Marks
Journal: Nat Microbiol Date: 2018-12-03 Impact factor: 17.745

Review 2. Heterogeneous bacterial persisters and engineering approaches to eliminate them.

Authors: Kyle R Allison; Mark P Brynildsen; James J Collins
Journal: Curr Opin Microbiol Date: 2011-09-19 Impact factor: 7.934

3. Antimicrobials: Promoting tolerance.

Authors: Andrew Jermy
Journal: Nat Rev Microbiol Date: 2011-12-16 Impact factor: 60.633

Review 4. Bugs, drugs and chemical genomics.

Authors: Terry Roemer; Julian Davies; Guri Giaever; Corey Nislow
Journal: Nat Chem Biol Date: 2011-12-15 Impact factor: 15.040

Review 5. New insights into bacterial adaptation through in vivo and in silico experimental evolution.

Authors: Thomas Hindré; Carole Knibbe; Guillaume Beslon; Dominique Schneider
Journal: Nat Rev Microbiol Date: 2012-03-27 Impact factor: 60.633

6. Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis.

Authors: Julian A Ferreras; Akash Gupta; Neal D Amin; Arijit Basu; Barij N Sinha; Stefan Worgall; Venkatesan Jayaprakash; Luis E N Quadri
Journal: Bioorg Med Chem Lett Date: 2011-08-26 Impact factor: 2.823

7. Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster.

Authors: Tina M Binz; Sonia I Maffioli; Margherita Sosio; Stefano Donadio; Rolf Müller
Journal: J Biol Chem Date: 2010-08-14 Impact factor: 5.157