| Literature DB >> 20439706 |
Lena Fadda1, Gwenoline Borhis, Parvin Ahmed, Kuldeep Cheent, Sophie V Pageon, Angelica Cazaly, Stavros Stathopoulos, Derek Middleton, Arend Mulder, Frans H J Claas, Tim Elliott, Daniel M Davis, Marco A Purbhoo, Salim I Khakoo.
Abstract
Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides promote clustering of KIR at the interface of effector and target cells, but do not result in inhibition of NK cells. Our data show that, as for T cells, small changes in the peptide content of MHC class I can regulate NK cell activity.Entities:
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Year: 2010 PMID： 20439706 PMCID： PMC2890497 DOI： 10.1073/pnas.0913745107
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205