Literature DB >> 20439681

Debating the value of spine surgery.

Edward N Hanley1, Harry N Herkowitz, John S Kirkpatrick, Jeffrey C Wang, Morgan N Chen, James D Kang.   

Abstract

Lumbar arthrodesis is a commonly performed operative procedure for the treatment of low back pain. Recently, total disc arthroplasty has gained some acceptance among surgeons and patients. However, the indications for and results of back pain surgery remain controversial and confusing. Available information suggests that meaningful functional improvement from these procedures is debatable and that the cost of such elective operations is high. Currently, lumbar disc replacement has gained minimal support from governmental and private payers. Among those attending this symposium at the 2009 Annual Meeting of the AOA, the vast majority concurred that Medicare and private insurance should not necessarily pay for disc replacement surgery. Interestingly, among this skeptical group of orthopaedic surgeons, only 23% believed that degeneration of the intervertebral disc is the major cause of low back pain. When asked the hypothetical question, "If you experienced chronic low back pain with degenerative changes at one level, what course of treatment would you opt for?" 61% responded that they would choose nonoperative treatment and 38%, that they would choose no treatment. Of more than 100 respondents, only one responded that he or she would undergo fusion and one admitted a willingness to undergo disc replacement in this hypothetical scenario.

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Year:  2010        PMID: 20439681     DOI: 10.2106/JBJS.I.01439

Source DB:  PubMed          Journal:  J Bone Joint Surg Am        ISSN: 0021-9355            Impact factor:   5.284


  21 in total

Review 1.  Diversity of intervertebral disc cells: phenotype and function.

Authors:  Girish Pattappa; Zhen Li; Marianna Peroglio; Nadine Wismer; Mauro Alini; Sibylle Grad
Journal:  J Anat       Date:  2012-06-11       Impact factor: 2.610

2.  Disposable instrumentation for lumbar pedicle screw and rod constructs.

Authors:  Antonio Faundez; Wendy Thompson; J-C Le Huec
Journal:  Eur Spine J       Date:  2013-12       Impact factor: 3.134

3.  Characterization of the annulus fibrosus-vertebral body interface: identification of new structural features.

Authors:  Y S Nosikova; J P Santerre; M Grynpas; G Gibson; R A Kandel
Journal:  J Anat       Date:  2012-07-03       Impact factor: 2.610

4.  Complications and Rates of Subsequent Lumbar Surgery Following Lumbar Total Disc Arthroplasty and Lumbar Fusion.

Authors:  Claire D Eliasberg; Michael P Kelly; Remi M Ajiboye; Nelson F SooHoo
Journal:  Spine (Phila Pa 1976)       Date:  2016-01       Impact factor: 3.468

Review 5.  Defects in intervertebral disc and spine during development, degeneration, and pain: New research directions for disc regeneration and therapy.

Authors:  Sarthak Mohanty; Chitra L Dahia
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2019-04-11       Impact factor: 5.814

6.  In vitro characterization of a stem-cell-seeded triple-interpenetrating-network hydrogel for functional regeneration of the nucleus pulposus.

Authors:  Lachlan J Smith; Deborah J Gorth; Brent L Showalter; Joseph A Chiaro; Elizabeth E Beattie; Dawn M Elliott; Robert L Mauck; Weiliam Chen; Neil R Malhotra
Journal:  Tissue Eng Part A       Date:  2014-03-21       Impact factor: 3.845

7.  Derivation of notochordal cells from human embryonic stem cells reveals unique regulatory networks by single cell-transcriptomics.

Authors:  Martha E Diaz-Hernandez; Nazir M Khan; Camila M Trochez; Tim Yoon; Peter Maye; Steven M Presciutti; Greg Gibson; Hicham Drissi
Journal:  J Cell Physiol       Date:  2019-12-16       Impact factor: 6.384

Review 8.  Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies.

Authors:  S Z Wang; Y F Rui; J Lu; C Wang
Journal:  Cell Prolif       Date:  2014-08-11       Impact factor: 6.831

9.  Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs.

Authors:  Kyung-Suk Choi; Chanmi Lee; Brian D Harfe
Journal:  Mech Dev       Date:  2012-07-25       Impact factor: 1.882

10.  Adenovirus-mediated GDF-5 promotes the extracellular matrix expression in degenerative nucleus pulposus cells.

Authors:  Xu-wei Luo; Kang Liu; Zhu Chen; Ming Zhao; Xiao-wei Han; Yi-guang Bai; Gang Feng
Journal:  J Zhejiang Univ Sci B       Date:  2016-01       Impact factor: 3.066

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