Literature DB >> 20437979

Bile acid malabsoption: a forgotten diagnosis?

Usman Khalid1, Amyn Lalji, Ruth Stafferton, Jervoise Andreyev.   

Abstract

Bile acid malabsorption (BAM) is never life threatening but can cause chronic symptoms. A survey of senior British gastroenterologists was conducted to examine their approach to patients with potential BAM. Of the 706 gastroenterologists contacted, 62% replied. Gastroenterologists see on average 500 new patients in clinic annually; 34% have chronic diarrhoea and 1% are diagnosed with BAM. In those with chronic diarrhoea, 6% of gastroenterologists investigate for BAM first line, while 61% consider the diagnosis only in selected patients or not at all. Sixty-one per cent of patients are diagnosed with type 1 BAM (secondary to terminal ileal disease), 22% have type 2 (idiopathic bile acid malabsorption) and 15% type 3 (unrelated to terminal ileal disease). Only one third of gastroenterologists use a definitive diagnostic test for BAM. BAM (particularly type 2) is under-diagnosed because it is frequently not considered and even when considered, many patients are not subjected to definitive diagnostic testing.

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Year:  2010        PMID: 20437979      PMCID: PMC4952080          DOI: 10.7861/clinmedicine.10-2-124

Source DB:  PubMed          Journal:  Clin Med (Lond)        ISSN: 1470-2118            Impact factor:   2.659


  16 in total

1.  Managing bile acid diarrhoea.

Authors:  Julian R F Walters; Sanjeev S Pattni
Journal:  Therap Adv Gastroenterol       Date:  2010-11       Impact factor: 4.409

2.  Rational investigations in irritable bowel syndrome.

Authors:  Christopher J Black; Alexander C Ford
Journal:  Frontline Gastroenterol       Date:  2019-06-06

3.  Serum Concentrations of 7α-hydroxy-4-cholesten-3-one Are Associated With Bile Acid Diarrhea in Patients With Crohn's Disease.

Authors:  Robert Battat; Marjolijn Duijvestein; Niels Vande Casteele; Siddharth Singh; Parambir S Dulai; Mark A Valasek; Larry Mimms; Judson McFarland; Kelly D Hester; Mark Renshaw; Anjali Jain; William J Sandborn; Brigid S Boland
Journal:  Clin Gastroenterol Hepatol       Date:  2018-11-15       Impact factor: 11.382

Review 4.  New insights into bile acid malabsorption.

Authors:  Ian Johnston; Jonathan Nolan; Sanjeev S Pattni; Julian R F Walters
Journal:  Curr Gastroenterol Rep       Date:  2011-10

5.  Outcomes from treating bile acid malabsorption using a multidisciplinary approach.

Authors:  Ankur Gupta; Ann C Muls; Amyn Lalji; Karen Thomas; Lorraine Watson; Clare Shaw; H Jervoise N Andreyev
Journal:  Support Care Cancer       Date:  2015-02-20       Impact factor: 3.603

6.  Design and characterization of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile Acid transporter activity.

Authors:  Diana Vivian; Kunrong Cheng; Sandeep Khurana; Su Xu; Valerie Whiterock; Drew Witter; Kimberley A Lentz; Kenneth S Santone; Jean-Pierre Raufman; James E Polli
Journal:  Pharm Res       Date:  2013-01-15       Impact factor: 4.200

Review 7.  Bile acid malabsorption in chronic diarrhea: pathophysiology and treatment.

Authors:  Alan N Barkun; Jonathan Love; Michael Gould; Henryk Pluta; Hillary Steinhart
Journal:  Can J Gastroenterol       Date:  2013-11       Impact factor: 3.522

8.  Design and evaluation of a novel trifluorinated imaging agent for assessment of bile acid transport using fluorine magnetic resonance imaging.

Authors:  Diana Vivian; Kunrong Cheng; Sandeep Khurana; Su Xu; Paul A Dawson; Jean-Pierre Raufman; James E Polli
Journal:  J Pharm Sci       Date:  2014-09-05       Impact factor: 3.534

9.  What is the cost of delayed diagnosis of bile acid malabsorption and bile acid diarrhoea?

Authors:  Darren C R Fernandes; Dennis Poon; Laura L White; H Jervoise N Andreyev
Journal:  Frontline Gastroenterol       Date:  2018-07-26

Review 10.  Challenging current views on bile acid diarrhoea and malabsorption.

Authors:  Matthew Kurien; Elizabeth Thurgar; Ashley Davies; Ron Akehurst; Jervoise Andreyev
Journal:  Frontline Gastroenterol       Date:  2017-06-29
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