AIMS: Prior studies have shown that HAART is associated with decreased HIV viral load in the lungs. The correlation between antiretroviral exposure in bronchoalveolar lavage (BAL) fluid and virologic response was evaluated in patients starting HAART and enrolled in The AIDS Clinical Trial Group Protocol 723. MATERIALS #ENTITYSTARTX00026; METHODS: A total of 24 subjects underwent blood and BAL sampling prior to starting HAART, and after 4 and 24 weeks of HAART. Drug concentrations and HIV RNA were measured in paired plasma and BAL samples. RESULTS: Antiretroviral drugs, including efavirenz, were detectable in BAL fluid of HIV-infected subjects beginning HAART. Efavirenz was also associated with a higher likelihood of clearing HIV RNA from the lungs. CONCLUSION: These results suggest the excellent pulmonary virologic response to antiretroviral therapy may, in part, be due to penetration of antiretroviral drugs into the alveolar compartment.
AIMS: Prior studies have shown that HAART is associated with decreased HIV viral load in the lungs. The correlation between antiretroviral exposure in bronchoalveolar lavage (BAL) fluid and virologic response was evaluated in patients starting HAART and enrolled in The AIDS Clinical Trial Group Protocol 723. MATERIALS #ENTITYSTARTX00026; METHODS: A total of 24 subjects underwent blood and BAL sampling prior to starting HAART, and after 4 and 24 weeks of HAART. Drug concentrations and HIV RNA were measured in paired plasma and BAL samples. RESULTS: Antiretroviral drugs, including efavirenz, were detectable in BAL fluid of HIV-infected subjects beginning HAART. Efavirenz was also associated with a higher likelihood of clearing HIV RNA from the lungs. CONCLUSION: These results suggest the excellent pulmonary virologic response to antiretroviral therapy may, in part, be due to penetration of antiretroviral drugs into the alveolar compartment.
Authors: Naser L Rezk; Richard R Tidwell; Angela D M Kashuba Journal: J Chromatogr B Analyt Technol Biomed Life Sci Date: 2003-07-05 Impact factor: 3.205
Authors: Moraima Guadalupe; Sumathi Sankaran; Michael D George; Elizabeth Reay; David Verhoeven; Barbara L Shacklett; Jason Flamm; Jacob Wegelin; Thomas Prindiville; Satya Dandekar Journal: J Virol Date: 2006-08 Impact factor: 5.103
Authors: Homer L Twigg Iii; Michael Weiden; Fred Valentine; Carol T Schnizlein-Bick; Roland Bassett; Lu Zheng; Joseph Wheat; Richard B Day; Helen Rominger; Ronald G Collman; Lawrence Fox; Barbara Brizz; Joan Dragavon; Robert W Coombs; R Pat Bucy Journal: J Infect Dis Date: 2008-01-01 Impact factor: 5.226
Authors: Kristina Crothers; Bruce W Thompson; Kathryn Burkhardt; Alison Morris; Sonia C Flores; Philip T Diaz; Richard E Chaisson; Gregory D Kirk; William N Rom; Laurence Huang Journal: Proc Am Thorac Soc Date: 2011-06
Authors: Julia Del Amo; Rosa Polo; Santiago Moreno; Asunción Díaz; Esteban Martínez; José Ramón Arribas; Inma Jarrín; Miguel A Hernán Journal: Ann Intern Med Date: 2020-06-26 Impact factor: 25.391
Authors: Nancy P Y Chung; K M Faisal Khan; Mirko Andreoli; Robert J Kaner; Sarah L O'Beirne; Ronald G Crystal Journal: Sci Rep Date: 2022-02-22 Impact factor: 4.379
Authors: Rosa Polo; Xabier García-Albéniz; Carolina Terán; Miguel Morales; David Rial-Crestelo; M Angeles Garcinuño; Miguel García Del Toro; César Hita; Juan Luis Gómez-Sirvent; Luis Buzón; Alberto Díaz de Santiago; Jose Pérez Arellano; Jesus Sanz; Pablo Bachiller; Elisa Martínez Alfaro; Vicente Díaz-Brito; Mar Masiá; Alicia Hernández-Torres; Jose M Guerra; Jesús Santos; Piedad Arazo; Leopoldo Muñoz; Jose Ramon Arribas; Pablo Martínez de Salazar; Santiago Moreno; Miguel A Hernán; Julia Del Amo Journal: Clin Microbiol Infect Date: 2022-08-05 Impact factor: 13.310