| Literature DB >> 20436553 |
Vaibhav Gaind1, Sumith Kularatne, Philip S Low, Kevin J Webb.
Abstract
We demonstrate the in vivo reconstruction of all fluorescence resonance energy transfer (FRET) parameters, including the nanometer donor-acceptor distance, in a mouse. The FRET chemical targets cancer cells, and on internalization, the acceptor is released, in lieu of a targeted anticancer drug in chemotherapy. Our method provides a new vehicle for studying disease by imaging FRET parameters in deep tissue.Entities:
Mesh:
Year: 2010 PMID: 20436553 DOI: 10.1364/OL.35.001314
Source DB: PubMed Journal: Opt Lett ISSN: 0146-9592 Impact factor: 3.776