OBJECTIVE: To analyze the longterm followup of a series of Brazilian patients with undifferentiated spondyloarthritis (uSpA). METHODS: Prospective study analyzing a group of 111 patients with the diagnosis of uSpA, fulfilling the European Spondylarthropathy Study Group and the Amor criteria, who were followed for 5 to 10 years in a single university referral center. Patients had their outcome analyzed at 5, 7, and 10 years. RESULTS: There was a predominance of men (81.1%), white ethnicity (78.4%), and positive HLA-B27 (61.3%), with a mean age at onset of 27.2 years. Twenty-seven patients presented development to ankylosing spondylitis (AS; 24.3%) and 3 to psoriatic arthritis (PsA; 2.7%), while 25 patients (22.5%) went into remission during the followup. Univariate logistic regression analysis revealed that ethnicity, HLA-B27, buttock pain, inflammatory low back pain, ankle involvement, grade I sacroiliitis at the beginning of the study, and the use of sulfasalazine were statistically associated with progression to AS. Multivariate logistic regression analysis revealed that HLA-B27 (p = 0.035, OR 6.720, 95% CI 11.45-39.43) and buttock pain (p = 0.009, OR 6.211, 95% CI 1.591-24.25) were statistically associated with progression to AS. CONCLUSION: In a longterm followup of 111 Brazilian patients with uSpA, HLA-B27 and buttock pain were significant predictors of progression to a definite disease.
OBJECTIVE: To analyze the longterm followup of a series of Brazilian patients with undifferentiated spondyloarthritis (uSpA). METHODS: Prospective study analyzing a group of 111 patients with the diagnosis of uSpA, fulfilling the European Spondylarthropathy Study Group and the Amor criteria, who were followed for 5 to 10 years in a single university referral center. Patients had their outcome analyzed at 5, 7, and 10 years. RESULTS: There was a predominance of men (81.1%), white ethnicity (78.4%), and positive HLA-B27 (61.3%), with a mean age at onset of 27.2 years. Twenty-seven patients presented development to ankylosing spondylitis (AS; 24.3%) and 3 to psoriatic arthritis (PsA; 2.7%), while 25 patients (22.5%) went into remission during the followup. Univariate logistic regression analysis revealed that ethnicity, HLA-B27, buttock pain, inflammatory low back pain, ankle involvement, grade I sacroiliitis at the beginning of the study, and the use of sulfasalazine were statistically associated with progression to AS. Multivariate logistic regression analysis revealed that HLA-B27 (p = 0.035, OR 6.720, 95% CI 11.45-39.43) and buttock pain (p = 0.009, OR 6.211, 95% CI 1.591-24.25) were statistically associated with progression to AS. CONCLUSION: In a longterm followup of 111 Brazilian patients with uSpA, HLA-B27 and buttock pain were significant predictors of progression to a definite disease.
Authors: U Kiltz; M Rudwaleit; J Sieper; D Krause; A Heiligenhaus; U Pleyer; J-F Chenot; A Stallmach; S Jaresch; U Oberschelp; E Schneider; B Swoboda; H Böhm; K-G Hermann; W-H Böhncke; J Braun Journal: Z Rheumatol Date: 2014-09 Impact factor: 1.372
Authors: Hellen M S de Carvalho; Adriana B Bortoluzzo; Célio R Gonçalves; José Antonio Braga da Silva; Antonio Carlos Ximenes; Manoel B Bértolo; Sandra L E Ribeiro; Mauro Keiserman; Rita Menin; Thelma L Skare; Sueli Carneiro; Valderílio F Azevedo; Walber P Vieira; Elisa N Albuquerque; Washington A Bianchi; Rubens Bonfiglioli; Cristiano Campanholo; Izaias P Costa; Angela P Duarte; Maria Bernadete O Gavi; Charles L Kohem; Nocy H Leite; Sonia A L Lima; Eduardo S Meirelles; Ivânio A Pereira; Marcelo M Pinheiro; Elizandra Polito; Gustavo G Resende; Francisco Airton C Rocha; Mittermayer B Santiago; Maria de Fátima L C Sauma; Percival D Sampaio-Barros Journal: Clin Rheumatol Date: 2011-12-28 Impact factor: 2.980