Literature DB >> 2043574

Use of orbital floor steroids in the management of patients with uniocular non-necrotising scleritis.

K N Hakin1, J Ham, S L Lightman.   

Abstract

Most cases of non-necrotising scleritis can be successfully treated with non-steroidal anti-inflammatory drugs. If these are ineffective, then high-dose systemic corticosteroids, with all their attendant side-effects, are usually required. We have used orbital floor injections of depot steroid in the management of nine patients with non-necrotising scleritis in an attempt to avoid the use of systemic steroids, or to allow the dose of steroids to be reduced while maintaining disease control. A temporary reduction in inflammation was achieved in all cases, which allowed the use of systemic steroids to be avoided altogether in two patients and delayed in the others. Non-steroidal anti-inflammatory drugs and systemic corticosteroids remain the mainstay of treatment for non-necrotising scleritis, but orbital floor injections may be a useful adjunct in certain cases.

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Year:  1991        PMID: 2043574      PMCID: PMC1042377          DOI: 10.1136/bjo.75.6.337

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN: 0007-1161            Impact factor:   4.638


  10 in total

1.  'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease.

Authors:  P A Meyer; P G Watson; W Franks; P Dubord
Journal:  Eye (Lond)       Date:  1987       Impact factor: 3.775

2.  Doyne Memorial Lecture, 1982. The nature and the treatment of scleral inflammation.

Authors:  P G Watson
Journal:  Trans Ophthalmol Soc U K       Date:  1982-07

3.  Immunosuppressive therapy for external ocular inflammatory disease.

Authors:  C S Foster
Journal:  Ophthalmology       Date:  1980-02       Impact factor: 12.079

Review 4.  Posterior scleritis.

Authors:  W E Benson
Journal:  Surv Ophthalmol       Date:  1988 Mar-Apr       Impact factor: 6.048

5.  Use of cyclosporin in the management of steroid dependent non-necrotising scleritis.

Authors:  K N Hakin; J Ham; S L Lightman
Journal:  Br J Ophthalmol       Date:  1991-06       Impact factor: 4.638

6.  Scleritis and episcleritis.

Authors:  P G Watson; S S Hayreh
Journal:  Br J Ophthalmol       Date:  1976-03       Impact factor: 4.638

7.  Cyclosporin therapy for severe scleritis.

Authors:  D Wakefield; P McCluskey
Journal:  Br J Ophthalmol       Date:  1989-09       Impact factor: 4.638

8.  Treatment of scleritis with combined oral prednisone and indomethacin therapy.

Authors:  B J Mondino; R B Phinney
Journal:  Am J Ophthalmol       Date:  1988-10-15       Impact factor: 5.258

9.  Posterior sub-Tenon's injections of corticosteroids in uveitis patients with cystoid macular edema.

Authors:  T Jennings; M M Rusin; H H Tessler; J G Cunha-Vaz
Journal:  Jpn J Ophthalmol       Date:  1988       Impact factor: 2.447

10.  Intravenous pulse methylprednisolone in scleritis.

Authors:  P McCluskey; D Wakefield
Journal:  Arch Ophthalmol       Date:  1987-06
  10 in total
  3 in total

Review 1.  Locally administered ocular corticosteroids: benefits and risks.

Authors:  Charles N J McGhee; Simon Dean; Helen Danesh-Meyer
Journal:  Drug Saf       Date:  2002       Impact factor: 5.606

Review 2.  Pharmacokinetics of ophthalmic corticosteroids.

Authors:  C N McGhee
Journal:  Br J Ophthalmol       Date:  1992-11       Impact factor: 4.638

3.  Ocular manifestation of rheumatoid arthritis-different forms and frequency.

Authors:  Gordana Zlatanović; Dragan Veselinović; Sonja Cekić; Maja Zivković; Jasmina Dorđević-Jocić; Marko Zlatanović
Journal:  Bosn J Basic Med Sci       Date:  2010-11       Impact factor: 3.363

  3 in total

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