C Reed1, I Goetz, E Vieta, M Bassi, J M Haro. 1. Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, Windlesham GU20 6PH, UK. reed_catherine@lilly.com
Abstract
OBJECTIVES: To explore factors associated with work impairment at 2 years following an acute episode. METHODS: European Mania in Bipolar disorder Longitudinal Evaluation of Medication (EMBLEM) is a prospective, observational study on the outcomes of patients with a manic/mixed episode. Work impairment was measured using a Longitudinal Interval Follow-up Evaluation (slice of LIFE) item and patients were categorised with either low or high work impairment at each observation. Baseline factors associated with work impairment at 2 years were assessed using multivariate modelling. RESULTS: At baseline (n=2289), 69% of patients had high work impairment. At 2 years (n=1393), high impairment reduced to 41%. Modelling identified rapid cycling as the strongest disease-related factor associated with high work impairment at 2 years, although high work impairment at baseline had the strongest association overall. Lower levels of education, recent admissions, CGI-BP overall severity in the 12 months prior to baseline and CGI-BP mania at baseline all predicted higher work impairment. Living together in a relationship and independent housing were both significantly associated with having low work impairment at 2 years. CONCLUSIONS: Work impairment in bipolar disorder is maintained over long periods, and is strongly associated with relationship status, living conditions and various disease-related factors.
OBJECTIVES: To explore factors associated with work impairment at 2 years following an acute episode. METHODS: European Mania in Bipolar disorder Longitudinal Evaluation of Medication (EMBLEM) is a prospective, observational study on the outcomes of patients with a manic/mixed episode. Work impairment was measured using a Longitudinal Interval Follow-up Evaluation (slice of LIFE) item and patients were categorised with either low or high work impairment at each observation. Baseline factors associated with work impairment at 2 years were assessed using multivariate modelling. RESULTS: At baseline (n=2289), 69% of patients had high work impairment. At 2 years (n=1393), high impairment reduced to 41%. Modelling identified rapid cycling as the strongest disease-related factor associated with high work impairment at 2 years, although high work impairment at baseline had the strongest association overall. Lower levels of education, recent admissions, CGI-BP overall severity in the 12 months prior to baseline and CGI-BP mania at baseline all predicted higher work impairment. Living together in a relationship and independent housing were both significantly associated with having low work impairment at 2 years. CONCLUSIONS:Work impairment in bipolar disorder is maintained over long periods, and is strongly associated with relationship status, living conditions and various disease-related factors.
Authors: Petri Arvilommi; Sanna Pallaskorpi; Outi Linnaranta; Kirsi Suominen; Sami Leppämäki; Hanna Valtonen; Erkki Isometsä Journal: Int J Bipolar Disord Date: 2022-07-11
Authors: C M Bonnín; C Torrent; J M Goikolea; M Reinares; B Solé; M Valentí; J Sánchez-Moreno; D Hidalgo; R Tabarés-Seisdedos; A Martínez-Arán; E Vieta Journal: Eur Arch Psychiatry Clin Neurosci Date: 2013-08-03 Impact factor: 5.270