No S Kim1, Mi M Ko, Min H Cha, Se-Mi Oh, Ok S Bang. 1. Brain Disease Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
Abstract
BACKGROUND: In our previous study, the neuropeptide Y (NPY) C-399T promoter polymorphism (rs16147C>T) was identified as a risk factor for ischemic stroke in Koreans. In this study, we investigated whether age and sex modify the genetic effect of C-399T on susceptibility to ischemic stroke. METHODS: A total of 1,350 subjects (802 ischemic stroke patients, 548 healthy controls) were genotyped for C-399T using a primer extension method. The results were statistically analyzed for the genetic association of C-399T with ischemic stroke and clinical parameters. RESULTS: The TT genotype for C-399T was observed at a significantly lower frequency in stroke patients relative to control (CC+CT vs. TT, odds ratio [OR]=0.578, 95% confidence interval [95% CI]=0.360-0.927, P<0.05). This trend was also observed in female (OR=0.495, 95% CI=0.240-1.022) and older subjects (y>60, OR=0.556, 95% CI=0.304-1.018) with borderline statistical significance (P=0.0571 and P=0.0574, respectively). However, C-399T allele frequency was not different between controls and stroke patients in any groups. The C-399T polymorphism was found to be associated with body mass index and levels of some blood lipids. CONCLUSIONS: The C-399T NPY promoter polymorphism should be considered a genetic risk factor for ischemic stroke in the older adult and female Korean populations. Copyright 2010 Elsevier B.V. All rights reserved.
BACKGROUND: In our previous study, the neuropeptide Y (NPY) C-399T promoter polymorphism (rs16147C>T) was identified as a risk factor for ischemic stroke in Koreans. In this study, we investigated whether age and sex modify the genetic effect of C-399T on susceptibility to ischemic stroke. METHODS: A total of 1,350 subjects (802 ischemic strokepatients, 548 healthy controls) were genotyped for C-399T using a primer extension method. The results were statistically analyzed for the genetic association of C-399T with ischemic stroke and clinical parameters. RESULTS: The TT genotype for C-399T was observed at a significantly lower frequency in strokepatients relative to control (CC+CT vs. TT, odds ratio [OR]=0.578, 95% confidence interval [95% CI]=0.360-0.927, P<0.05). This trend was also observed in female (OR=0.495, 95% CI=0.240-1.022) and older subjects (y>60, OR=0.556, 95% CI=0.304-1.018) with borderline statistical significance (P=0.0571 and P=0.0574, respectively). However, C-399T allele frequency was not different between controls and strokepatients in any groups. The C-399T polymorphism was found to be associated with body mass index and levels of some blood lipids. CONCLUSIONS: The C-399T NPY promoter polymorphism should be considered a genetic risk factor for ischemic stroke in the older adult and female Korean populations. Copyright 2010 Elsevier B.V. All rights reserved.
Authors: Dong Hwan Kim; Seung Don Yoo; Jinmann Chon; Dong Hwan Yun; Hee-Sang Kim; Hae Jeong Park; Su Kang Kim; Joo-Ho Chung; Jin Kyu Kang; Seung Ah Lee Journal: J Korean Med Sci Date: 2016-02-16 Impact factor: 2.153