Coordinating different homeostatic processes.

In this issue of Neuron, Bergquist and colleagues study a rapid form of presynaptic homeostatic regulation at the Drosophila neuromuscular junction. They show that the K(+) channel genes shal and shaker are reciprocally regulated in the central nervous system and suggest a hierarchical organization of intrinsic and synaptic homeostatic regulatory processes. Copyright 2010 Elsevier Inc. All rights reserved.