| Literature DB >> 20434978 |
Daniel Sauter1, Anke Specht, Frank Kirchhoff.
Abstract
Mammalian cells are equipped with so-called "restriction factors" that suppress virus replication and help to prevent virus transmission from one species to another. This Essay discusses the host restriction factor tetherin, which blocks the release of enveloped viruses like HIV-1, and the factors evolved by primate lentiviruses, such as Vpu and Nef, that antagonize tetherin's action. 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID: 20434978 DOI: 10.1016/j.cell.2010.04.022
Source DB: PubMed Journal: Cell ISSN: 0092-8674 Impact factor: 41.582