BACKGROUND: As it is unknown whether complete asthma remission or progression of asthma is associated with airway inflammation and remodeling, we assessed these characteristics in bronchial biopsies of relevant subsets of asthma patients. METHODS: Sputum and bronchial biopsies were obtained from asthma patients in remission (PC(20) histamine> 32 mg/ml, PC(20) AMP> 320 mg/ml) and from those with either a slow FEV(1) decline (< 30 ml/year) or fast decline (> 30 ml/year). Inflammatory cells and mediators were determined in sputum, inflammatory cells and aspects of airway remodeling in bronchial biopsies. RESULTS: Asthmatics in remission and asthma patients with a slow FEV(1) decline had a similar extent of airway inflammation and remodeling in sputum and bronchial biopsies. Asthma patients with a fast FEV(1) decline had high sputum eosinophil numbers. Moreover, FEV(1) decline (ml/year) correlated with sputum eosinophil numbers (Rs=0.51, p=0.003) and ECP levels (Rs=0.57, p=0.001). Airway remodeling, i.e. basement membrane thickness, correlated with sputum eosinophils (Rs=0.69, p<0.001), sputum ECP (Rs=0.46, p=0.018) and airway wall eosinophil numbers (Rs=0.49, p=0.002). CONCLUSIONS: Asthma, even when in remission, is accompanied by airway inflammation and remodeling. Data suggest that eosinophils are important in a subset of asthma patients by association to accelerated FEV(1) decline and change of basement membrane thickness.
BACKGROUND: As it is unknown whether complete asthma remission or progression of asthma is associated with airway inflammation and remodeling, we assessed these characteristics in bronchial biopsies of relevant subsets of asthmapatients. METHODS: Sputum and bronchial biopsies were obtained from asthmapatients in remission (PC(20) histamine> 32 mg/ml, PC(20) AMP> 320 mg/ml) and from those with either a slow FEV(1) decline (< 30 ml/year) or fast decline (> 30 ml/year). Inflammatory cells and mediators were determined in sputum, inflammatory cells and aspects of airway remodeling in bronchial biopsies. RESULTS: Asthmatics in remission and asthmapatients with a slow FEV(1) decline had a similar extent of airway inflammation and remodeling in sputum and bronchial biopsies. Asthmapatients with a fast FEV(1) decline had high sputum eosinophil numbers. Moreover, FEV(1) decline (ml/year) correlated with sputum eosinophil numbers (Rs=0.51, p=0.003) and ECP levels (Rs=0.57, p=0.001). Airway remodeling, i.e. basement membrane thickness, correlated with sputum eosinophils (Rs=0.69, p<0.001), sputum ECP (Rs=0.46, p=0.018) and airway wall eosinophil numbers (Rs=0.49, p=0.002). CONCLUSIONS:Asthma, even when in remission, is accompanied by airway inflammation and remodeling. Data suggest that eosinophils are important in a subset of asthmapatients by association to accelerated FEV(1) decline and change of basement membrane thickness.
Authors: Stephane Esnault; Elizabeth A B Kelly; Zhong-Jian Shen; Mats W Johansson; James S Malter; Nizar N Jarjour Journal: J Immunol Date: 2015-08-14 Impact factor: 5.422
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Authors: Marzyeh Amini; Dinara Bashirova; Bram P Prins; Eva Corpeleijn; Marcel Bruinenberg; Lude Franke; Pim van der Harst; Gerjan Navis; Bruce H R Wolffenbuttel; Ronald P Stolk; Cisca Wijmenga; Dirkje S Postma; Gerard H Koppelman; H Marike Boezen; Judith Vonk; Harold Snieder; Behrooz Z Alizadeh Journal: PLoS One Date: 2016-12-15 Impact factor: 3.240
Authors: Stephane Esnault; Elizabeth A Kelly; Elizabeth A Schwantes; Lin Ying Liu; Larissa P DeLain; Jami A Hauer; Yury A Bochkov; Loren C Denlinger; James S Malter; Sameer K Mathur; Nizar N Jarjour Journal: PLoS One Date: 2013-07-02 Impact factor: 3.240