OBJECTIVES: To compare the effectiveness and safety of mifepristone/misoprostol versus intra-amniotic injection of ethacridine lactate for the termination of second trimester pregnancy. STUDY DESIGN:210 women requesting voluntary termination of pregnancies at between 16 and 24 weeks of gestation were randomly assigned into two groups. Group 1 (MM) received a single oral dose of 200 mg mifepristone and, 36-48 h later, 400 microg of misoprostol vaginally, with up to three additional oral doses of 400 microg misoprostol every 12 h. Group 2 (EL) received an intra-amniotic injection of 100mg ethacridine lactate. The primary outcome was successful abortion rate. Secondary outcomes included the difference in the induction-to-abortion interval and the frequency of adverse events. RESULTS: Both MM and EL regimens were effective, with successful abortion rates of 96.19% and 94.29%, respectively (P=0.746). The complete abortion rates were 68.57% and 70.48%, respectively. The induction-to-abortion interval was longer in the MM group than in the EL group (50.57+/-6.80 h vs. 43.02+/-8.74 h, respectively, P<0.001). Both treatments were safe, although there was a significant difference in rates of gastrointestinal and fever adverse events between the two groups. CONCLUSIONS: Both MM and EL regimens were effective with high success rates and were safe for the termination of second trimester pregnancy. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
RCT Entities:
OBJECTIVES: To compare the effectiveness and safety of mifepristone/misoprostol versus intra-amniotic injection of ethacridine lactate for the termination of second trimester pregnancy. STUDY DESIGN: 210 women requesting voluntary termination of pregnancies at between 16 and 24 weeks of gestation were randomly assigned into two groups. Group 1 (MM) received a single oral dose of 200 mg mifepristone and, 36-48 h later, 400 microg of misoprostol vaginally, with up to three additional oral doses of 400 microg misoprostol every 12 h. Group 2 (EL) received an intra-amniotic injection of 100mg ethacridine lactate. The primary outcome was successful abortion rate. Secondary outcomes included the difference in the induction-to-abortion interval and the frequency of adverse events. RESULTS: Both MM and EL regimens were effective, with successful abortion rates of 96.19% and 94.29%, respectively (P=0.746). The complete abortion rates were 68.57% and 70.48%, respectively. The induction-to-abortion interval was longer in the MM group than in the EL group (50.57+/-6.80 h vs. 43.02+/-8.74 h, respectively, P<0.001). Both treatments were safe, although there was a significant difference in rates of gastrointestinal and fever adverse events between the two groups. CONCLUSIONS: Both MM and EL regimens were effective with high success rates and were safe for the termination of second trimester pregnancy. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Lianne E Rotin; Neil MacLean; Ahmed Aman; Marcela Gronda; Feng-Hsu Lin; Rose Hurren; XiaoMing Wang; Jeffrey L Wrana; Alessandro Datti; Rima Al-Awar; Mark D Minden; Aaron D Schimmer Journal: Haematologica Date: 2016-09-01 Impact factor: 9.941