| Literature DB >> 20434334 |
Robert L Davis1, Mehmet Kahraman, Thomas J Prins, Yan Beaver, Travis G Cook, Jessica Cramp, Charmagne S Cayanan, Elisabeth M M Gardiner, Marsha A McLaughlin, Abbot F Clark, Mark R Hellberg, Andrew K Shiau, Stewart A Noble, Allen J Borchardt.
Abstract
We identified a new benzothiophene containing Rho kinase inhibitor scaffold in an ultra high-throughput enzymatic activity screen. SAR studies, driven by a novel label-free cellular impedance assay, were used to derive 39, which substantially reduced intraocular pressure in a monkey model of glaucoma-associated ocular hypertension. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20434334 DOI： 10.1016/j.bmcl.2010.04.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823