| Literature DB >> 20434139 |
David Koos1, Steven F Josephs, Doru T Alexandrescu, Ray Chun-Fai Chan, Famela Ramos, Vladimir Bogin, Vincent Gammill, Constantin A Dasanu, Rosalia De Necochea-Campion, Neil H Riordan, Ewa Carrier.
Abstract
Induction of tumor-specific immunity is an attractive approach to cancer therapy, however to date every major pivotal trial has resulted in failure. While the phenomena of tumor-mediated immune suppression has been known for decades, only recently have specific molecular pathways been elucidated, and for the first time, rationale means of intervening and observing results of intervention have been developed. In this review we describe major advances in our understanding of tumor escape from immunological pressure and provide some possible therapeutic scenarios for enhancement of efficacy in future cancer vaccine trials. Copyright (c) 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20434139 DOI： 10.1016/j.cellimm.2010.03.019
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868