BACKGROUND: Cancer patients with venous thromboembolism (VTE) have an increased incidence of bleeding complications while on anticoagulant therapy. METHODS: RIETE is an ongoing registry of consecutive patients with acute VTE. We tried to identify which cancer patients are at a higher risk for major bleeding. RESULTS: Up to May 2009, 4,709 patients with active cancer had been enrolled in RIETE registry. During the first 3 months of anticoagulant therapy, 200 (4.2%) patients developed major bleeding. Then, 38 (0.8%) further patients bled beyond the first 90 days of therapy, 3 bled after withholding anticoagulant therapy. The most common sites of bleeding were the gastrointestinal tract (118 patients, 49%), genitourinary system (43 patients, 18%) and the brain (27 patients, 11%). In all, 160 patients (66%) died within 30 days after bleeding: 88 (55%) died of bleeding, 3 (1.9%) died of recurrent pulmonary embolism. CONCLUSIONS: Major bleeding is a frequent and severe complication in cancer patients with VTE, even beyond the third month. One third of the patients who bled died due the bleeding event.
BACKGROUND:Cancerpatients with venous thromboembolism (VTE) have an increased incidence of bleeding complications while on anticoagulant therapy. METHODS: RIETE is an ongoing registry of consecutive patients with acute VTE. We tried to identify which cancerpatients are at a higher risk for major bleeding. RESULTS: Up to May 2009, 4,709 patients with active cancer had been enrolled in RIETE registry. During the first 3 months of anticoagulant therapy, 200 (4.2%) patients developed major bleeding. Then, 38 (0.8%) further patients bled beyond the first 90 days of therapy, 3 bled after withholding anticoagulant therapy. The most common sites of bleeding were the gastrointestinal tract (118 patients, 49%), genitourinary system (43 patients, 18%) and the brain (27 patients, 11%). In all, 160 patients (66%) died within 30 days after bleeding: 88 (55%) died of bleeding, 3 (1.9%) died of recurrent pulmonary embolism. CONCLUSIONS: Major bleeding is a frequent and severe complication in cancerpatients with VTE, even beyond the third month. One third of the patients who bled died due the bleeding event.
Authors: I Mahé; H Puget; J C Buzzi; M Lamuraglia; J Chidiac; A Strukov; Hélène Helfer; A Perozziello Journal: Support Care Cancer Date: 2016-03-16 Impact factor: 3.603
Authors: Corinne Frere; Carme Font; Francis Esposito; Benjamin Crichi; Philippe Girard; Nicolas Janus Journal: Support Care Cancer Date: 2021-10-06 Impact factor: 3.359