Literature DB >> 2043144

A gene structure of testosterone 6 beta-hydroxylase (P450IIIA).

M Miyata1, K Nagata, Y Yamazoe, R Kato.   

Abstract

Genomic clones of a rat testosterone 6 beta-hydroxylase have been isolated and characterized as the first gene (P450/6 beta A) among P450IIIA subfamily. This gene spans about 25Kb and consists of 13 exons, which is the largest number of exons among cytochrome P-450 genes reported previously. The nucleotide sequence of the exon region showed high similarity to those of P450PCN2 and P450PCN1 cDNA (Gonzalez, F.J. et al. (1987) Mol. Cell. Biol. 2969-2974), but several replacements and deletions of nucleotide were found between the P450/6 beta A gene and both cDNAs, indicating the existence of multiple P450IIIA genes in rats.

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Year:  1991        PMID： 2043144     DOI： 10.1016/0006-291x(91)91949-d

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


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Authors: 
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2.  Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif.

Authors:  J M Huss; S I Wang; A Astrom; P McQuiddy; C B Kasper
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3.  Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes.

Authors:  H J Burger; J D Schuetz; E G Schuetz; P S Guzelian
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  3 in total

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