Feedforward-feedback multiple predictive controllers for glucose regulation in type 1 diabetes.

Type 1 diabetic patients depend on insulin therapy to maintain blood glucose levels within safe range. The idea behind the "Artificial Pancreas" is to mimic, as close as possible, the functions of the natural pancreas in glucose sensing and insulin delivery, by using closed-loop control techniques. This work presents a model-based predictive control strategy for blood glucose regulation in diabetic patients. The controller is provided with a feedforward loop to improve meal compensation, a gain scheduling scheme to improve the controller performance in controlling the nonlinear glucose-insulin system, and an asymmetric cost function to reduce the hypoglycemic risk. Simulation scenarios with virtual patients are used to test the designed controller. The obtained results show a good controller performance in fasting conditions and meal disturbance rejection, and robustness against measurements errors, meal estimation errors, and changes in insulin sensitivity. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.