Literature DB >> 20430440

Immunolocalization of NK-1 receptor and Substance P in human normal placenta.

M Muñoz1, A Pavón, M Rosso, M V Salinas, A Pérez, A Carranza, A González-Ortega.   

Abstract

A role for Substance P (SP) in human placenta is not known, although is possible that regulates placental physiology through the Neurokinin (NK)-1 receptor. Ten human normal placenta tissues were studied by immunohistochemistry to demonstrate the localization of NK-1 receptor and SP. An immunostaining pattern for NK-1 receptor and SP was observed in the endothelium and myocytes of fetal blood vessels, decidua and trophoblast. The SP is located in both the cytoplasm and the nucleus whereas NK-1 receptor in cytoplasmic. These findings reported here for the fist time, suggest a role for the SP and NK-1 receptor in the placental physiology.

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Year:  2010        PMID： 20430440     DOI： 10.1016/j.placenta.2010.03.015

Source DB:  PubMed          Journal:  Placenta        ISSN： 0143-4004            Impact factor:   3.481


  9 in total

Review 1.  The substance P/NK-1 receptor system: NK-1 receptor antagonists as anti-cancer drugs.

Authors:  Miguel Munoz; Rafael Covenas; Francisco Esteban; Maximino Redondo
Journal:  J Biosci       Date:  2015-06       Impact factor: 1.826

Review 2.  Neurokinin receptors and their implications in various autoimmune diseases.

Authors:  Amrita Mishra; Girdhari Lal
Journal:  Curr Res Immunol       Date:  2021-07-01

Review 3.  Biological and Pharmacological Aspects of the NK1-Receptor.

Authors:  Susana Garcia-Recio; Pedro Gascón
Journal:  Biomed Res Int       Date:  2015-09-03       Impact factor: 3.411

Review 4.  Neurokinin-1 receptor antagonists as antitumor drugs in gastrointestinal cancer: A new approach.

Authors:  Miguel Muñoz; Rafael Coveñas
Journal:  Saudi J Gastroenterol       Date:  2016 Jul-Aug       Impact factor: 2.485

5.  The substance P and neurokinin-1 receptor system in human thyroid cancer: an immunohistochemical study.

Authors:  Inmaculada Isorna; Francisco Esteban; Juan Solanellas; Rafael Coveñas; Miguel Muñoz
Journal:  Eur J Histochem       Date:  2020-04-28       Impact factor: 3.188

6.  Elevated Neurokinin-1 Receptor Expression in Uterine Products of Conception Is Associated With First Trimester Miscarriages.

Authors:  Ahmad Alwazzan; Riffat Mehboob; Amber Hassan; Shahida Perveen; Syed Amir Gilani; Fridoon Jawad Ahmad; Imrana Tanvir; Masroor Elahi Babar; Muhammad Akram Tariq; Gibran Ali; Shehla Javed Akram; Rizwan Ullah Khan; Javed Akram
Journal:  Front Physiol       Date:  2020-12-18       Impact factor: 4.566

Review 7.  Substance P and Neurokinin 1 Receptor in Chronic Inflammation and Cancer of the Head and Neck: A Review of the Literature.

Authors:  Francisco Esteban; Pablo Ramos-García; Miguel Muñoz; Miguel Ángel González-Moles
Journal:  Int J Environ Res Public Health       Date:  2021-12-30       Impact factor: 3.390

8.  Bilateral increase in expression and concentration of tachykinin in a unilateral rabbit muscle overuse model that leads to myositis.

Authors:  Yafeng Song; Per S Stål; Ji-Guo Yu; Sture Forsgren
Journal:  BMC Musculoskelet Disord       Date:  2013-04-12       Impact factor: 2.362

9.  Marked Effects of Tachykinin in Myositis Both in the Experimental Side and Contralaterally: Studies on NK-1 Receptor Expressions in an Animal Model.

Authors:  Yafeng Song; Per S Stål; Jiguo Yu; Sture Forsgren
Journal:  ISRN Inflamm       Date:  2013-01-29
  9 in total

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