A possible case of mixed mania due to neurosarcoidosis treated successfully with methylprednisolone and ziprasidone: another example of frontal-subcortical disinhibition?

Sarcoidosis is an idiopathic systemic granulomatous disease recognized by clinical and radiographic findings, which ultimately require histopathologic confirmation of noncaseating granulomas for a definitive diagnosis. Psychiatric manifestations occur in 20% of patient with neurosarcoidosis [http://dynaweb.ebscohost.com.chekov.evms.edu/Detail.aspx?id=306337&sid=bdce39cc-d2bd-4977-9e4d-786f2e768d57@sessionmgr4]. We present a case of suspected mixed mania due to neurosarcoidosis, with the manic symptoms responding early and robustly to ziprasidone. Copyright 2010. Published by Elsevier Inc.