Literature DB >> 20430243

Euprolactinemic galactorrhea associated with use of imipramine and escitalopram in a postmenopausal woman.

Rajnarayan Mahasuar1, Pratima Majhi, Jayprakash Rusell Ravan.   

Abstract

Hormonal side effects of antidepressants are infrequent, and galactorrhea is seldom mentioned among tricyclic antidepressant (TCA) and selective serotonin reuptake inhibitor (SSRI)-related side effects. Antidepressants can directly stimulate postsynaptic 5-HT receptors in the hypothalamus or indirectly inhibit the tuberoinfundibular dopaminergic neurons through 5-HT, which may increase prolactin levels and later cause galactorrhea. We describe a case of euprolactinemic galactorrhea in a postmenopausal woman, induced by imipramine and escitalopram. This report highlights the presence of unidentified novel mechanisms of antidepressant-induced galactorrhea and other possible contributors. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2009        PMID： 20430243     DOI： 10.1016/j.genhosppsych.2009.07.006

Source DB:  PubMed          Journal:  Gen Hosp Psychiatry        ISSN： 0163-8343            Impact factor:   3.238


  6 in total

1.  Serotonin reuptake inhibitors and hyperprolactinaemia: a case/non-case study in the French pharmacovigilance database.

Authors:  Thierry Trenque; Emmanuelle Herlem; Pascal Auriche; Moustapha Dramé
Journal:  Drug Saf       Date:  2011-12-01       Impact factor: 5.606

2.  Chronic escitalopram treatment restores spatial learning, monoamine levels, and hippocampal long-term potentiation in an animal model of depression.

Authors:  V Bhagya; B N Srikumar; T R Raju; B S Shankaranarayana Rao
Journal:  Psychopharmacology (Berl)       Date:  2010-11-04       Impact factor: 4.530

3.  Sertraline Induced Galactorrhea.

Authors:  Eylem Özten; Gökben Hizli Sayar; Işıl Göğçegöz Gül; Mehmet Emin Ceylan
Journal:  Noro Psikiyatr Ars       Date:  2015-06-01       Impact factor: 1.339

4.  Marked mydriasis and neuritis nervi optici associated with galactorrhea following citalopram treatment: a case report and discussion.

Authors:  Horst J Koch; Heike Zellmer
Journal:  Case Rep Med       Date:  2011-08-15

5.  Paroxetine-induced galactorrhea.

Authors:  Prannay Gulati; B S Chavan; Subhash Das
Journal:  Indian J Psychiatry       Date:  2014-10       Impact factor: 1.759

6.  Effect of antipsychotics on breast tumors by analysis of the Japanese Adverse Drug Event Report database and cell-based experiments.

Authors:  Tae Maeshima; Ryosuke Iijima; Machiko Watanabe; Satoru Yui; Fumio Itagaki
Journal:  J Pharm Health Care Sci       Date:  2021-04-01
  6 in total

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