Literature DB >> 20430031

Discovery of veterinary antiparasitic agents in the 21st century: a view from industry.

Debra J Woods1, Christopher S Knauer.   

Abstract

Discovery of antiparasitic agents is a challenging process, requiring discovery of molecules with the ability to kill parasites but not their hosts. Customer preference is for fewer doses and ease of application, but this is not always compatible with reduced withdrawal times, human food safety and/or user safety. This article describes some of the difficulties faced by researchers in the search for new antiparasitic agents, while highlighting advances that may improve the discovery process and the chance of success in discovering novel drugs. Copyright 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20430031     DOI： 10.1016/j.ijpara.2010.04.005

Source DB:  PubMed          Journal:  Int J Parasitol        ISSN： 0020-7519            Impact factor:   3.981


  11 in total

Review 1.  Ion channels and receptor as targets for the control of parasitic nematodes.

Authors:  Adrian J Wolstenholme
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2011-10-14       Impact factor: 4.077

2.  In vitro synergistic effect of amphotericin B and allicin on Leishmania donovani and L. infantum.

Authors:  M J Corral; E González-Sánchez; M Cuquerella; J M Alunda
Journal:  Antimicrob Agents Chemother       Date:  2013-12-23       Impact factor: 5.191

Review 3.  Major prospects for exploring canine vector borne diseases and novel intervention methods using 'omic technologies.

Authors:  Robin B Gasser; Cinzia Cantacessi; Bronwyn E Campbell; Andreas Hofmann; Domenico Otranto
Journal:  Parasit Vectors       Date:  2011-04-13       Impact factor: 3.876

4.  An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni.

Authors:  Helen L Whiteland; Anand Chakroborty; Josephine E Forde-Thomas; Alessandra Crusco; Alan Cookson; Jackie Hollinshead; Caroline A Fenn; Barbara Bartholomew; Peter A Holdsworth; Maggie Fisher; Robert J Nash; Karl F Hoffmann
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2018-10-26       Impact factor: 4.077

5.  RNA interference in the cat flea, Ctenocephalides felis: Approaches for sustained gene knockdown and evidence of involvement of Dicer-2 and Argonaute2.

Authors:  Catriona H Edwards; John Baird; Erich Zinser; Debra J Woods; Sophie Shaw; Ewan M Campbell; Alan S Bowman
Journal:  Int J Parasitol       Date:  2018-09-24       Impact factor: 3.981

6.  Drug-efflux and target-site gene expression patterns in Haemonchus contortus larvae able to survive increasing concentrations of levamisole in vitro.

Authors:  Ranbir S Sarai; Steven R Kopp; Glen T Coleman; Andrew C Kotze
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2014-03-13       Impact factor: 4.077

7.  Polymorphism in ion channel genes of Dirofilaria immitis: Relevant knowledge for future anthelmintic drug design.

Authors:  Thangadurai Mani; Catherine Bourguinat; Kathy Keller; Elena Carreton; Andrew Peregrine; Roger K Prichard
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2016-07-01       Impact factor: 4.077

Review 8.  Farmer Behavior and Gastrointestinal Nematodes in Ruminant Livestock-Uptake of Sustainable Control Approaches.

Authors:  Fiona Vande Velde; Johannes Charlier; Edwin Claerebout
Journal:  Front Vet Sci       Date:  2018-10-16

Review 9.  Drug resistance in liver flukes.

Authors:  I Fairweather; G P Brennan; R E B Hanna; M W Robinson; P J Skuce
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2020-01-10       Impact factor: 4.077

10.  Long-read RNA sequencing of human and animal filarial parasites improves gene models and discovers operons.

Authors:  Nicolas J Wheeler; Paul M Airs; Mostafa Zamanian
Journal:  PLoS Negl Trop Dis       Date:  2020-11-16
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