BACKGROUND: Although the TIMI score is the one most frequently used in acute coronary syndromes (ACS) without ST-segment elevation, the GRACE score has potential prognostic superiority, as it was created based on an observational registry, part of the variables is treated in a semi-quantitative form and renal function is taken into account in its calculation. OBJECTIVE: To test the hypothesis that the GRACE risk score has superior in-hospital prognostic value, when compared to the TIMI score in patients admitted with ACS. METHODS: Individuals with unstable angina or myocardial infarction without ST-segment elevation, consecutively admitted at the Coronary Unit between August 2007 and January 2009, were included in the study. RESULTS: A total of 154 patients aged 71 +/- 13 years, of which 56% were females, with a GRACE median of 117 and a TIMI median of 3 were studied. During the hospitalization period, the incidence of events was 8.4% (12 deaths and 1 non-fatal infarction). The Hosmer-Lemeshow test applied to the GRACE score presented an chi2 of 5.3 (P = 0.72), whereas the TIMI score presented an chi2 of 1.85 (P = 0.60). Therefore, both scores presented good calibration. As for the analysis of discrimination, the GRACE score presented a C-statistics of 0.91 (95%CI= 0.86 - 0.97), significantly superior to the C-statistics of 0.69 of the TIMI score (95%CI = 0.55 - 0.84) - P = 0.02 for the difference between the scores. CONCLUSION: Regarding the prediction of hospital events in patients with ACS, the GRACE score has superior prognostic capacity when compared to the TIMI score.
BACKGROUND: Although the TIMI score is the one most frequently used in acute coronary syndromes (ACS) without ST-segment elevation, the GRACE score has potential prognostic superiority, as it was created based on an observational registry, part of the variables is treated in a semi-quantitative form and renal function is taken into account in its calculation. OBJECTIVE: To test the hypothesis that the GRACE risk score has superior in-hospital prognostic value, when compared to the TIMI score in patients admitted with ACS. METHODS: Individuals with unstable angina or myocardial infarction without ST-segment elevation, consecutively admitted at the Coronary Unit between August 2007 and January 2009, were included in the study. RESULTS: A total of 154 patients aged 71 +/- 13 years, of which 56% were females, with a GRACE median of 117 and a TIMI median of 3 were studied. During the hospitalization period, the incidence of events was 8.4% (12 deaths and 1 non-fatal infarction). The Hosmer-Lemeshow test applied to the GRACE score presented an chi2 of 5.3 (P = 0.72), whereas the TIMI score presented an chi2 of 1.85 (P = 0.60). Therefore, both scores presented good calibration. As for the analysis of discrimination, the GRACE score presented a C-statistics of 0.91 (95%CI= 0.86 - 0.97), significantly superior to the C-statistics of 0.69 of the TIMI score (95%CI = 0.55 - 0.84) - P = 0.02 for the difference between the scores. CONCLUSION: Regarding the prediction of hospital events in patients with ACS, the GRACE score has superior prognostic capacity when compared to the TIMI score.
Authors: Luis C L Correia; Felipe Ferreira; Felipe Kalil; André Silva; Luisa Pereira; Manuela Carvalhal; Maurício Cerqueira; Fernanda Lopes; Nicole de Sá; Márcia Noya-Rabelo Journal: Arq Bras Cardiol Date: 2015-06-02 Impact factor: 2.000
Authors: Luis C L Correia; Guilherme Garcia; Felipe Kalil; Felipe Ferreira; Manuela Carvalhal; Ruan Oliveira; André Silva; Isis Vasconcelos; Caio Henri; Márcia Noya-Rabelo Journal: Arq Bras Cardiol Date: 2014-07-15 Impact factor: 2.000
Authors: Mateus Dos Santos Viana; Fernanda Lopes; Antonio Mauricio Dos Santos Cerqueira Junior; Jessica Gonzalez Suerdieck; André Barcelos da Silva; Ana Clara Barcelos da Silva; Thiago Menezes Barbosa de Souza; Manuela Campelo Carvalhal; Marcia Maria Noya Rabelo; Luis Claudio Lemos Correia Journal: Arq Bras Cardiol Date: 2017-11-13 Impact factor: 2.000
Authors: Adriana Carla Bridi; Roberto Carlos Lyra da Silva; Carolina Correa Pinto de Farias; Andrezza Serpa Franco; Viviane de Lima Quintas dos Santos Journal: Rev Bras Ter Intensiva Date: 2014 Jan-Mar