BACKGROUND: The prediction of pulmonary hemodynamic data from non-invasive assessment could exempt some patients with congenital cardiac septal defects from preoperative invasive assessment (catheterization). OBJECTIVE: To determine, in simultaneous assessment, whether data obtained from Doppler echocardiography could predict aspects of pulmonary hemodynamics in such patients. METHODS: Echocardiographic parameters related to systolic and systemic pulmonary flow and pulmonary venous flow were related to hemodynamic data in 30 consecutive patients with cardiac septal defects (aged 4 months to 58 years, median 2.2 years, mean pulmonary artery pressure between 16 and 93 mmHg). RESULTS: The velocity-time integrals of systolic flow in right ventricle outflow tract (VTI RVOT > or = 22 cm) and pulmonary venous flow (VTI VP > or = 20 cm) predicted PVR/SVR <; 0.1 levels (pulmonary vascular resistance and systemic vascular resistance ratio), with a specificity of 0.81 and odds ratio above 1.0. For VTI RVOT > or = 27 cm and VTI PV > 24 cm values, the specificity was higher than 0.90 and odds ratio 2.29 and 4.47 respectively. The ratio between pulmonary and systemic flows (Qp/Qs > 2.89 and > or = 4.0, echocardiographic estimates) was useful in predicting Qp/Qs > 3.0 values through catheterization (specificity of 0.78 and 0.91, odds ratio 1.14 and 2.97, respectively). CONCLUSION: In patients with cardiac septal defects, Doppler echocardiography is able to identify those at increased flow and low pulmonary vascular resistance.
BACKGROUND: The prediction of pulmonary hemodynamic data from non-invasive assessment could exempt some patients with congenital cardiac septal defects from preoperative invasive assessment (catheterization). OBJECTIVE: To determine, in simultaneous assessment, whether data obtained from Doppler echocardiography could predict aspects of pulmonary hemodynamics in such patients. METHODS: Echocardiographic parameters related to systolic and systemic pulmonary flow and pulmonary venous flow were related to hemodynamic data in 30 consecutive patients with cardiac septal defects (aged 4 months to 58 years, median 2.2 years, mean pulmonary artery pressure between 16 and 93 mmHg). RESULTS: The velocity-time integrals of systolic flow in right ventricle outflow tract (VTI RVOT > or = 22 cm) and pulmonary venous flow (VTI VP > or = 20 cm) predicted PVR/SVR <; 0.1 levels (pulmonary vascular resistance and systemic vascular resistance ratio), with a specificity of 0.81 and odds ratio above 1.0. For VTI RVOT > or = 27 cm and VTI PV > 24 cm values, the specificity was higher than 0.90 and odds ratio 2.29 and 4.47 respectively. The ratio between pulmonary and systemic flows (Qp/Qs > 2.89 and > or = 4.0, echocardiographic estimates) was useful in predicting Qp/Qs > 3.0 values through catheterization (specificity of 0.78 and 0.91, odds ratio 1.14 and 2.97, respectively). CONCLUSION: In patients with cardiac septal defects, Doppler echocardiography is able to identify those at increased flow and low pulmonary vascular resistance.
Authors: Antonio Augusto Lopes; Robyn J Barst; Sheila Glennis Haworth; Marlene Rabinovitch; Maha Al Dabbagh; Maria Jesus Del Cerro; Dunbar Ivy; Tarek Kashour; Krishna Kumar; S Harikrishnan; Michele D'Alto; Ana Maria Thomaz; Leína Zorzanelli; Vera D Aiello; Ana Olga Mocumbi; Maria Virginia T Santana; Ahmed Nasser Galal; Hanaa Banjar; Omar Tamimi; Alexandra Heath; Patricia C Flores; Gabriel Diaz; Julio Sandoval; Shyam Kothari; Shahin Moledina; Rilvani C Gonçalves; Alessandra C Barreto; Maria Angélica Binotto; Margarida Maia; Fahad Al Habshan; Ian Adatia Journal: Pulm Circ Date: 2014-06 Impact factor: 3.017
Authors: Maria Francilene S Souza; Juliano G Penha; Nair Y Maeda; Filomena R B G Galas; Kelly C O Abud; Eloisa S Carvalho; Ana Maria Thomaz; Claudia R P Castro; Juliana Pereira; Antonio Augusto Lopes Journal: Mediators Inflamm Date: 2022-01-15 Impact factor: 4.711