Literature DB >> 20427629

Development of a recombinant epsilon toxoid vaccine against enterotoxemia and its use as a combination vaccine with live attenuated sheep pox virus against enterotoxemia and sheep pox.

Dev Chandran1, Sureddi Satyam Naidu, Parthasarathy Sugumar, Gudavalli Sudha Rani, Shahana Pallichera Vijayan, Deepika Mathur, Lalit C Garg, Villuppanoor Alwar Srinivasan.   

Abstract

Sheep pox and enterotoxemia are important diseases of sheep, and these diseases cause severe economic losses to sheep farmers. The present study was undertaken to evaluate the potential of formaldehyde-inactivated recombinant epsilon toxin as a vaccine candidate. The potency of the recombinant epsilon toxoid with aluminum hydroxide as an adjuvant in sheep was determined. Vaccinated sheep were protected against enterotoxemia, with potency values of >5 IU being protective. Further, the use of this construct in a combination vaccine against sheep pox resulted in the sheep being protected against both sheep pox and enterotoxemia.

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Year:  2010        PMID： 20427629      PMCID： PMC2884421          DOI： 10.1128/CVI.00013-10

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  19 in total

Review 1.  Environmental signals controlling expression of virulence determinants in bacteria.

Authors:  J J Mekalanos
Journal:  J Bacteriol       Date:  1992-01       Impact factor: 3.490

2.  Structural studies on epsilon-prototoxin of Clostridium perfringens type D. Localization of the site of tryptic scission necessary for activation to epsilon-toxin.

Authors:  A S Bhown; A F Habeerb
Journal:  Biochem Biophys Res Commun       Date:  1977-10-10       Impact factor: 3.575

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Cloning and nucleotide sequencing of the Clostridium perfringens epsilon-toxin gene and its expression in Escherichia coli.

Authors:  S E Hunter; I N Clarke; D C Kelly; R W Titball
Journal:  Infect Immun       Date:  1992-01       Impact factor: 3.441

5.  Vaccine containing iron-regulated proteins of Pasteurella haemolytica A2 enhances protection against experimental pasteurellosis in lambs.

Authors:  N J Gilmour; W Donachie; A D Sutherland; J S Gilmour; G E Jones; M Quirie
Journal:  Vaccine       Date:  1991-02       Impact factor: 3.641

6.  Local and systemic antibody response in infants after oral administration of inactivated enteropathogenic E. coli serotype O111 and O55.

Authors:  R Lodinová-Zádníková; B Korych; K Gajdostíková
Journal:  Folia Microbiol (Praha)       Date:  1990       Impact factor: 2.099

7.  Analysis of immunization route-related variation in the immune response to heat-killed Salmonella typhimurium in mice.

Authors:  J Thatte; S Rath; V Bal
Journal:  Infect Immun       Date:  1995-01       Impact factor: 3.441

8.  Molecular cloning of Clostridium perfringens epsilon-toxin gene and its high level expression in E. coli.

Authors:  P P Goswami; P Rupa; N S Prihar; L C Garg
Journal:  Biochem Biophys Res Commun       Date:  1996-09-24       Impact factor: 3.575

Review 9.  Progress towards sheep and goat pox vaccines.

Authors:  P Kitching
Journal:  Vaccine       Date:  1983-12       Impact factor: 3.641

10.  The pathology of peracute experimental Clostridium perfringens type D enterotoxemia in sheep.

Authors:  F A Uzal; W R Kelly; W E Morris; J Bermudez; M Baisón
Journal:  J Vet Diagn Invest       Date:  2004-09       Impact factor: 1.279
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  9 in total

Review 1.  Recombinant Alpha, Beta, and Epsilon Toxins of Clostridium perfringens: Production Strategies and Applications as Veterinary Vaccines.

Authors:  Marcos Roberto A Ferreira; Gustavo Marçal S G Moreira; Carlos Eduardo P da Cunha; Marcelo Mendonça; Felipe M Salvarani; Ângela N Moreira; Fabricio R Conceição
Journal:  Toxins (Basel)       Date:  2016-11-21       Impact factor: 4.546

2.  Cloning and expression of Clostridium perfringens type D vaccine strain epsilon toxin gene in E. coli as a recombinant vaccine candidate.

Authors:  Parastoo Aziminia; Reza Pilehchian-Langroudi; Kasra Esmaeilnia
Journal:  Iran J Microbiol       Date:  2016-08

3.  Evaluation of plant-produced <i>Clostridium perfringens</i> type D <i>epsilon</i> toxoid in a vaccine against enterotoxaemia in sheep.

Authors:  Tinyiko Mokoena; Ereck Chakauya; Michael Crampton; Boet Weyers; Malefa Tselanyane; Tsepo Tsekoa; Rachel Chikwamba
Journal:  Onderstepoort J Vet Res       Date:  2017-04-25       Impact factor: 1.792

4.  Prevalence, Genotypic and Phenotypic Characterization and Antibiotic Resistance Profile of Clostridium perfringens Type A and D Isolated from Feces of Sheep (Ovis aries) and Goats (Capra hircus) in Punjab, Pakistan.

Authors:  Mudassar Mohiuddin; Zahid Iqbal; Abubakar Siddique; Shenquan Liao; Muhammad Khalid Farooq Salamat; Nanshan Qi; Ayesha Mohiud Din; Mingfei Sun
Journal:  Toxins (Basel)       Date:  2020-10-14       Impact factor: 4.546

5.  Recombinant unpurified rETXH106P/ CTB-rETXY196E protects rabbits against Clostridium perfringens epsilon toxin.

Authors:  Xiaobing Peng; Xuni Li; Guorui Peng; Lifang Feng; Yuwen Jiang; Yufeng Luo
Journal:  J Vet Med Sci       Date:  2021-02-08       Impact factor: 1.267

6.  Immunogenic and neutralization efficacy of recombinant perfringolysin O of Clostridium perfringens and its C-terminal receptor-binding domain in a murine model.

Authors:  Ankita Singh; Prashant Rawat; Devapriya Choudhury; Aparna Dixit
Journal:  Immunol Res       Date:  2022-01-15       Impact factor: 4.505

7.  Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia.

Authors:  Monika Bokori-Brown; Charlotte A Hall; Charlotte Vance; Sérgio P Fernandes da Costa; Christos G Savva; Claire E Naylor; Ambrose R Cole; Ajit K Basak; David S Moss; Richard W Titball
Journal:  Vaccine       Date:  2014-04-05       Impact factor: 3.641

8.  Immunization with a novel Clostridium perfringens epsilon toxin mutant rETX(Y196E)-C confers strong protection in mice.

Authors:  Wenwu Yao; Jingjing Kang; Lin Kang; Shan Gao; Hao Yang; Bin Ji; Ping Li; Jing Liu; Wenwen Xin; Jinglin Wang
Journal:  Sci Rep       Date:  2016-04-06       Impact factor: 4.379

9.  Toxin-neutralizing antibodies protect against Clostridium perfringens-induced necrosis in an intestinal loop model for bovine necrohemorrhagic enteritis.

Authors:  Evy Goossens; Stefanie Verherstraeten; Bonnie R Valgaeren; Bart Pardon; Leen Timbermont; Stijn Schauvliege; Diego Rodrigo-Mocholí; Freddy Haesebrouck; Richard Ducatelle; Piet R Deprez; Filip Van Immerseel
Journal:  BMC Vet Res       Date:  2016-06-13       Impact factor: 2.741
  9 in total

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