BACKGROUND: Some years ago, Spain registered a much lower colorectal cancer (CRC) incidence and mortality rate than did other European countries but the rates have since converged. This study sought to compare time trends for CRC incidence and mortality, identify change-points in these trends and thereby update available information in Spain. METHODS: Incidence data were drawn from all population-based cancer registries in Spain which participated in the European Network of Cancer Registries and had been collecting data for at least 10 consecutive years during the period 1975-2004. Colorectal cancer corresponded to codes 153, 154 and 159.0 of the International Classification of Diseases ninth revision (ICD-9) and codes C18-C21 and C26.0 of the ICD-10. In all, the 13 registries included in this study cover approximately 26% of the total Spanish population. We evaluated the time trends in incidence and mortality using transition change-point and age-period-cohort models. RESULTS: Our results revealed an important increase in CRC incidence in Spain, which held constant across the entire study period but became slightly attenuated in both sexes around 1995, when a change-point was detected. The annual increase in incidence, which had been 4.3% per annum in men up to this point, declined to 2.5% thereafter. In women, the increase in incidence, albeit also of considerable magnitude, was more moderate. The incidence trend contrasted sharply with that for mortality, inasmuch as the latter changed in 1997-98, after which point mortality rates in both sexes began to decline. CONCLUSIONS: The divergence between incidence (upward trend) and mortality rates (downward trend from the mid-1990s onwards) would suggest that possible explanations may lie in improved accessibility to endoscopy increased early detection with a corresponding shift to an earlier disease stage and improvements in therapy. This trend is having important consequences insofar as disease prevalence and burden of care are concerned.
BACKGROUND: Some years ago, Spain registered a much lower colorectal cancer (CRC) incidence and mortality rate than did other European countries but the rates have since converged. This study sought to compare time trends for CRC incidence and mortality, identify change-points in these trends and thereby update available information in Spain. METHODS: Incidence data were drawn from all population-based cancer registries in Spain which participated in the European Network of Cancer Registries and had been collecting data for at least 10 consecutive years during the period 1975-2004. Colorectal cancer corresponded to codes 153, 154 and 159.0 of the International Classification of Diseases ninth revision (ICD-9) and codes C18-C21 and C26.0 of the ICD-10. In all, the 13 registries included in this study cover approximately 26% of the total Spanish population. We evaluated the time trends in incidence and mortality using transition change-point and age-period-cohort models. RESULTS: Our results revealed an important increase in CRC incidence in Spain, which held constant across the entire study period but became slightly attenuated in both sexes around 1995, when a change-point was detected. The annual increase in incidence, which had been 4.3% per annum in men up to this point, declined to 2.5% thereafter. In women, the increase in incidence, albeit also of considerable magnitude, was more moderate. The incidence trend contrasted sharply with that for mortality, inasmuch as the latter changed in 1997-98, after which point mortality rates in both sexes began to decline. CONCLUSIONS: The divergence between incidence (upward trend) and mortality rates (downward trend from the mid-1990s onwards) would suggest that possible explanations may lie in improved accessibility to endoscopy increased early detection with a corresponding shift to an earlier disease stage and improvements in therapy. This trend is having important consequences insofar as disease prevalence and burden of care are concerned.
Authors: Imane Allali; Susana Delgado; Pablo Isidro Marron; Aurora Astudillo; Jen Jen Yeh; Hassan Ghazal; Saaïd Amzazi; Temitope Keku; M Andrea Azcarate-Peril Journal: Gut Microbes Date: 2015
Authors: J Galceran; A Ameijide; M Carulla; A Mateos; J R Quirós; D Rojas; A Alemán; A Torrella; M Chico; M Vicente; J M Díaz; N Larrañaga; R Marcos-Gragera; M J Sánchez; J Perucha; P Franch; C Navarro; E Ardanaz; J Bigorra; P Rodrigo; R Peris Bonet Journal: Clin Transl Oncol Date: 2017-01-16 Impact factor: 3.405
Authors: J Ribes; L Esteban; R Clèries; J Galceran; R Marcos-Gragera; R Gispert; A Ameijide; M L Vilardell; J Borras; A Puigdefabregas; M Buxó; A Freitas; A Izquierdo; J M Borras Journal: Clin Transl Oncol Date: 2013-12-12 Impact factor: 3.405
Authors: Gemma Binefa; Francisco Rodríguez-Moranta; Alex Teule; Manuel Medina-Hayas Journal: World J Gastroenterol Date: 2014-06-14 Impact factor: 5.742
Authors: Maria Ramos; Maria Llagostera; Magdalena Esteva; Elena Cabeza; Xavier Cantero; Manel Segarra; Maria Martín-Rabadán; Guillem Artigues; Maties Torrent; Joana Maria Taltavull; Joana Maria Vanrell; Mercè Marzo; Joan Llobera Journal: BMC Cancer Date: 2011-09-25 Impact factor: 4.430
Authors: Gonzalo López-Abente; Javier García-Pérez; Pablo Fernández-Navarro; Elena Boldo; Rebeca Ramis Journal: BMC Public Health Date: 2012-08-01 Impact factor: 3.295