BACKGROUND: This article affords an overview of the patterns and time trends of childhood cancer incidence (1983-2002) and survival (1991-2002) in Spain. PATIENTS AND METHODS: A population-based study was conducted, including 5936 cases for incidence and 3257 for survival analyses. Differences in incidence were tested with the standardised incidence ratio. Trends were analysed for all tumours, and for all malignant, haematological, central nervous system (CNS) (all and only malignant) and other solid tumours. Incidence trends were analysed using Poisson and Bayesian joinpoint models. Observed, relative and age-adjusted survival rates were calculated, and trends were tested using the log-rank test. RESULTS: The incidence pattern in Spain was similar to that in Europe. Rates, both overall and for leukaemias, lymphomas, CNS, soft tissue and, remarkably, for sympathetic nervous system and bone tumours, were high. Upward incidence trends were present for all tumour groups. All groups, except solid tumours (excluding CNS), displayed a change-point centred around 1990-95, after which the trend stopped rising. Five-year survival increased significantly across the period for all groups, except for CNS tumours. Recent survival results were in line with Italy, the UK and the European average. CONCLUSIONS: To confirm these results, ongoing surveillance of incidence and survival trends, and studies targeting specific tumours are called for.
BACKGROUND: This article affords an overview of the patterns and time trends of childhood cancer incidence (1983-2002) and survival (1991-2002) in Spain. PATIENTS AND METHODS: A population-based study was conducted, including 5936 cases for incidence and 3257 for survival analyses. Differences in incidence were tested with the standardised incidence ratio. Trends were analysed for all tumours, and for all malignant, haematological, central nervous system (CNS) (all and only malignant) and other solid tumours. Incidence trends were analysed using Poisson and Bayesian joinpoint models. Observed, relative and age-adjusted survival rates were calculated, and trends were tested using the log-rank test. RESULTS: The incidence pattern in Spain was similar to that in Europe. Rates, both overall and for leukaemias, lymphomas, CNS, soft tissue and, remarkably, for sympathetic nervous system and bone tumours, were high. Upward incidence trends were present for all tumour groups. All groups, except solid tumours (excluding CNS), displayed a change-point centred around 1990-95, after which the trend stopped rising. Five-year survival increased significantly across the period for all groups, except for CNS tumours. Recent survival results were in line with Italy, the UK and the European average. CONCLUSIONS: To confirm these results, ongoing surveillance of incidence and survival trends, and studies targeting specific tumours are called for.
Authors: R Marcos-Gragera; M Solans; J Galceran; R Fernández-Delgado; A Fernández-Teijeiro; A Mateos; J R Quirós-Garcia; N Fuster-Camarena; V De Castro; M J Sánchez; P Franch; M D Chirlaque; E Ardanaz; C Martos; D Salmerón; R Peris-Bonet Journal: Clin Transl Oncol Date: 2018-04-05 Impact factor: 3.405
Authors: J A Ortega-García; F A López-Hernández; E Sobrino-Najul; I Febo; J L Fuster-Soler Journal: An Pediatr (Barc) Date: 2011-04 Impact factor: 1.500
Authors: Juan A Ortega-García; Fernando A López-Hernández; José L Fuster-Soler; Juan F Martínez-Lage Journal: Childs Nerv Syst Date: 2011-06-08 Impact factor: 1.475
Authors: R Marcos-Gragera; J Galceran; C Martos; A L de Munain; M Vicente-Raneda; C Navarro; J R Quirós-Garcia; M-J Sánchez; E Ardanaz; M Ramos; A Mateos; D Salmerón; S Felipe; R Peris-Bonet Journal: Clin Transl Oncol Date: 2016-07-22 Impact factor: 3.405
Authors: Ryan Koshy Mathew; Roddy O'Kane; Roger Parslow; Charles Stiller; Tom Kenny; Susan Picton; Paul Dominic Chumas Journal: Neuro Oncol Date: 2014-05-05 Impact factor: 12.300
Authors: Nerea Larrañaga; M José Sanchez; Eva Ardanaz; Saray Felipe; Rafael Marcos-Gragera; María Ramos; Marià Carulla; M Dolores Chirlaque; Marcial V Argüelles; Carmen Martos; Antonio Mateo; Rafael Peris-Bonet Journal: J Cancer Date: 2016-01-10 Impact factor: 4.207