| Literature DB >> 20426398 |
Takashi Tomioka1, Yusuke Takahashi, Trey G Vaughan, Takayoshi Yanase.
Abstract
A simple three-step single-pot procedure for Z-stereoselective synthesis of beta-monosubstituted acrylonitriles has been established. The reaction involves olefination of aldehydes with an in situ generated alpha-diaminoboryl carbanion species. Various aromatic and aliphatic aldehydes were smoothly converted into the corresponding (Z)-olefin products (up to 96:4 ratio) in good yields (80-98%).Entities:
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Year: 2010 PMID： 20426398 DOI： 10.1021/ol100534s
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005