BACKGROUND: Chronic hepatitis C (CHC) virus infection in patients with cirrhosis is difficult to treat. There is limited data on the outcome of treatment for genotype 3 HCV infection with cirrhosis. AIMS: To determine sustained virological response (SVR) and its predictive factors in patients with cirrhosis due to genotype 3 HCV infection treated with pegylated interferon and ribavirin (RBV). METHODS: Consecutive patients with compensated cirrhosis due to HCV genotype 3 with positive HCV RNA treated with peg-IFN and RBV in our Gastroenterology Clinics during November 2005 to December 2006 were included in this study. Cirrhosis was diagnosed on the basis of liver biopsy and/or biochemical testing and ultrasound of abdomen. Primary end point of treatment was SVR. RESULTS: Of 66 patients, 32 (48.5%) were male. The mean age was 46.2 +/- 10.1 years; there were 61 (92.4%) patients with Child's A cirrhosis followed by 5 (7.6%) with Child's B type. 33 (50%) patients received pegylated interferon alfa-2a (180 microg/wk) with ribavirin and 33 (50%) received pegylated interferon alfa 2b (1 microg/kg/week) with ribavirin. EVR was achieved in 44 (66.7%), and ETR in 46 (69.7%); overall SVR was achieved in 38 (57.6%) patients. Factors predictive of SVR were age (p value = 0.03), treatment naïve status (p value = 0.04) and EVR (p value < 0.001). Five patients were unable to complete the treatment due to side effects or cytopenias. CONCLUSIONS: Treatment of patients with HCV genotype 3, compensated cirrhosis, with pegylated interferon and ribavirin is effective and well tolerated.
BACKGROUND:Chronic hepatitis C (CHC) virus infection in patients with cirrhosis is difficult to treat. There is limited data on the outcome of treatment for genotype 3 HCV infection with cirrhosis. AIMS: To determine sustained virological response (SVR) and its predictive factors in patients with cirrhosis due to genotype 3 HCV infection treated with pegylated interferon and ribavirin (RBV). METHODS: Consecutive patients with compensated cirrhosis due to HCV genotype 3 with positive HCV RNA treated with peg-IFN and RBV in our Gastroenterology Clinics during November 2005 to December 2006 were included in this study. Cirrhosis was diagnosed on the basis of liver biopsy and/or biochemical testing and ultrasound of abdomen. Primary end point of treatment was SVR. RESULTS: Of 66 patients, 32 (48.5%) were male. The mean age was 46.2 +/- 10.1 years; there were 61 (92.4%) patients with Child's A cirrhosis followed by 5 (7.6%) with Child's B type. 33 (50%) patients received pegylated interferon alfa-2a (180 microg/wk) with ribavirin and 33 (50%) received pegylated interferon alfa 2b (1 microg/kg/week) with ribavirin. EVR was achieved in 44 (66.7%), and ETR in 46 (69.7%); overall SVR was achieved in 38 (57.6%) patients. Factors predictive of SVR were age (p value = 0.03), treatment naïve status (p value = 0.04) and EVR (p value < 0.001). Five patients were unable to complete the treatment due to side effects or cytopenias. CONCLUSIONS: Treatment of patients with HCV genotype 3, compensated cirrhosis, with pegylated interferon and ribavirin is effective and well tolerated.
Authors: Nathan Ford; Catherine Kirby; Kasha Singh; Edward J Mills; Graham Cooke; Adeeba Kamarulzaman; Philipp duCros Journal: Bull World Health Organ Date: 2012-02-03 Impact factor: 9.408
Authors: Muhammad Ali; Samia Afzal; Asad Zia; Ahmed Hassan; Ali Talha Khalil; Muhammad Ovais; Zabta Khan Shinwari; Muhammad Idrees Journal: Medicine (Baltimore) Date: 2016-12 Impact factor: 1.889