Literature DB >> 20425016

The genetics of juvenile idiopathic arthritis: what is new in 2010?

Sheila Angeles-Han1, Sampath Prahalad.   

Abstract

Juvenile idiopathic arthritis (JIA), the most common cause of chronic arthritis in children, is believed to be influenced by genetic factors. Recent studies on the genetics of JIA have not only validated proposed genetic associations but have also led to the recognition of novel genetic associations. Studies of specific genes have been modeled on the premise of shared autoimmunity, wherein genetic variants that predispose to other autoimmune phenotypes may also confer susceptibility to JIA. The advent of genome-wide association studies has accelerated the detection of non-HLA susceptibility loci in other autoimmune phenotypes and is likely to uncover novel JIA-associated variants as well. This review highlights recent genetic investigations of JIA.

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Year:  2010        PMID： 20425016     DOI： 10.1007/s11926-010-0087-0

Source DB:  PubMed          Journal:  Curr Rheumatol Rep        ISSN： 1523-3774            Impact factor:   4.592


  48 in total

Review 1.  Juvenile idiopathic arthritis.

Authors:  Angelo Ravelli; Alberto Martini
Journal:  Lancet       Date:  2007-03-03       Impact factor: 79.321

2.  Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

Authors:  Robert M Plenge; Chris Cotsapas; Leela Davies; Alkes L Price; Paul I W de Bakker; Julian Maller; Itsik Pe'er; Noel P Burtt; Brendan Blumenstiel; Matt DeFelice; Melissa Parkin; Rachel Barry; Wendy Winslow; Claire Healy; Robert R Graham; Benjamin M Neale; Elena Izmailova; Ronenn Roubenoff; Alexander N Parker; Roberta Glass; Elizabeth W Karlson; Nancy Maher; David A Hafler; David M Lee; Michael F Seldin; Elaine F Remmers; Annette T Lee; Leonid Padyukov; Lars Alfredsson; Jonathan Coblyn; Michael E Weinblatt; Stacey B Gabriel; Shaun Purcell; Lars Klareskog; Peter K Gregersen; Nancy A Shadick; Mark J Daly; David Altshuler
Journal:  Nat Genet       Date:  2007-11-04       Impact factor: 38.330

3.  Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

Authors:  Robert M Plenge; Leonid Padyukov; Elaine F Remmers; Shaun Purcell; Annette T Lee; Elizabeth W Karlson; Frederick Wolfe; Daniel L Kastner; Lars Alfredsson; David Altshuler; Peter K Gregersen; Lars Klareskog; John D Rioux
Journal:  Am J Hum Genet       Date:  2005-11-01       Impact factor: 11.025

Review 4.  Divergent roles for C-type lectins expressed by cells of the innate immune system.

Authors:  Eamon P McGreal; Luisa Martinez-Pomares; Siamon Gordon
Journal:  Mol Immunol       Date:  2004-11       Impact factor: 4.407

5.  Juvenile rheumatoid arthritis in affected sibpairs.

Authors:  M B Moroldo; B L Tague; E S Shear; D N Glass; E H Giannini
Journal:  Arthritis Rheum       Date:  1997-11

6.  The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis.

Authors:  H M Albers; F A S Kurreeman; J J Houwing-Duistermaat; D M C Brinkman; S S M Kamphuis; H J Girschick; C Wouters; M A J Van Rossum; W Verduijn; R E M Toes; T W J Huizinga; M W Schilham; R ten Cate
Journal:  Ann Rheum Dis       Date:  2008-07-01       Impact factor: 19.103

7.  Chromosomal region 16p13: further evidence of increased predisposition to immune diseases.

Authors:  A Martínez; N Perdigones; M C Cénit; L Espino; J Varadé; J R Lamas; J L Santiago; M Fernández-Arquero; H de la Calle; R Arroyo; E G de la Concha; B Fernández-Gutiérrez; E Urcelay
Journal:  Ann Rheum Dis       Date:  2010-01       Impact factor: 19.103

8.  Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.

Authors:  E Y M G Fung; D J Smyth; J M M Howson; J D Cooper; N M Walker; H Stevens; L S Wicker; J A Todd
Journal:  Genes Immun       Date:  2008-12-25       Impact factor: 2.676

9.  Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis.

Authors:  Anne Hinks; Anne Barton; Neil Shephard; Steve Eyre; John Bowes; Michele Cargill; Eric Wang; Xiayi Ke; Giulia C Kennedy; Sally John; Jane Worthington; Wendy Thomson
Journal:  Arthritis Rheum       Date:  2009-01

10.  Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.

Authors:  Anne Barton; Wendy Thomson; Xiayi Ke; Steve Eyre; Anne Hinks; John Bowes; Laura Gibbons; Darren Plant; Anthony G Wilson; Ioanna Marinou; Ann Morgan; Paul Emery; Sophia Steer; Lynne Hocking; David M Reid; Paul Wordsworth; Pille Harrison; Jane Worthington
Journal:  Hum Mol Genet       Date:  2008-04-22       Impact factor: 6.150
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  7 in total

1.  Synovium, synergy and serendipity.

Authors:  Gregory M Pastores
Journal:  J Inherit Metab Dis       Date:  2011-10       Impact factor: 4.982

2.  An Update on Treatment of Pediatric Chronic Non-Infectious Uveitis.

Authors:  Arjun B Sood; Sheila T Angeles-Han
Journal:  Curr Treatm Opt Rheumatol       Date:  2017-01-29

3.  PADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis.

Authors:  Kaori Hisa; Masakatsu D Yanagimachi; Takuya Naruto; Takako Miyamae; Masako Kikuchi; Rhoki Hara; Tomoyuki Imagawa; Shumpei Yokota; Masaaki Mori
Journal:  PLoS One       Date:  2017-02-09       Impact factor: 3.240

4.  Validity and feasibility of the self-report EQ-5D-Y as a generic Health-Related Quality of Life outcome measure in children and adolescents with Juvenile Idiopathic Arthritis in Western Cape, South Africa.

Authors:  Desiree Scott; Christiaan Scott; Jennifer Jelsma; Deepthi Abraham; Janine Verstraete
Journal:  S Afr J Physiother       Date:  2019-07-30

5.  CLARITY - ChiLdhood Arthritis Risk factor Identification sTudY.

Authors:  Justine A Ellis; Anne-Louise Ponsonby; Angela Pezic; Raul A Chavez; Roger C Allen; Jonathan D Akikusa; Jane E Munro
Journal:  Pediatr Rheumatol Online J       Date:  2012-11-15       Impact factor: 3.054

6.  Meta-analysis confirms association between TNFA-G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA.

Authors:  Merlyn J Kaalla; K Alaine Broadaway; Mina Rohani-Pichavant; Karen N Conneely; April Whiting; Lori Ponder; David T Okou; Sheila Angeles-Han; Kelly Rouster-Stevens; Milton R Brown; Larry B Vogler; Lynn B Jorde; John F Bohnsack; Michael P Epstein; Sampath Prahalad
Journal:  Pediatr Rheumatol Online J       Date:  2013-10-25       Impact factor: 3.054

7.  The biologic basis of clinical heterogeneity in juvenile idiopathic arthritis.

Authors:  Simon W M Eng; Trang T Duong; Alan M Rosenberg; Quaid Morris; Rae S M Yeung
Journal:  Arthritis Rheumatol       Date:  2014-12       Impact factor: 10.995
  7 in total

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