Atypical lipoleiomyoma of the uterus.

A case of uterine atypical lipoleiomyoma in a 55-year-old obese woman is described. Histologically it was composed of atypical smooth muscle tissue and adipose tissue, as proved by immunohistochemical staining and ultrastructural study. Moreover, these studies revealed a transition from tumor smooth muscle cells to lipocytes. The features of this tumor suggest that at least some lipoleiomyomas result from lipomatous metaplasia of leiomyoma. Lipoleiomyoma is a rare lesion of the uterus, and the present tumor with an atypical leiomyomatous appearance is the first reported case of its kind. A review of previous case reports, together with the condition of this patient, revealed that patients with lipoleiomyoma are often overweight and menopausal, and have a high incidence of gallbladder disease.