Literature DB >> 20423612

Inhibitory effects of polyphenols isolated from Rhus verniciflua on Aldo-keto reductase family 1 B10.

Dae-Geun Song1, Joo Young Lee, Eun Ha Lee, Sang Hoon Jung, Chu Won Nho, Kwang Hyun Cha, Song Yi Koo, Cheol-Ho Pan.   

Abstract

Aldo-keto reductase family 1 B10 (AKR1B10) is a member of the NADPH-dependent aldo-keto reductase (AKR) superfamily, and has been considered to be a potential cancer therapeutic target. Total extract from the bark of Rhus verniciflua (Toxicodendron vernicifluum (Stokes)) showed AKR1B10 inhibitory activity. To identify the active compounds from R. verniciflua responsible for AKR1B10 inhibition, nine compounds were isolated via bioactivity-guided isolation and tested for their effects against recombinant human AKR1B10 (rhAKR1B10). Results showed that butein, isolated from the ethyl acetate fraction, was most able to inhibit rhAKR1B10. The inhibitory rate of butein against rhAKR1B10 was 42.86% at 1 microM with an IC(50) value of 1.47 microM, and enzyme kinetic analysis revealed its inhibition mode to be uncompetitive.

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Year:  2010        PMID： 20423612     DOI： 10.5483/bmbrep.2010.43.4.268

Source DB:  PubMed          Journal:  BMB Rep        ISSN： 1976-6696            Impact factor:   4.778


  5 in total

1.  Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers.

Authors:  Toshiyuki Matsunaga; Yasuhiro Wada; Satoshi Endo; Midori Soda; Ossama El-Kabbani; Akira Hara
Journal:  Front Pharmacol       Date:  2012-01-31       Impact factor: 5.810

Review 2.  Rhus verniciflua stokes against advanced cancer: a perspective from the Korean Integrative Cancer Center.

Authors:  Woncheol Choi; Hyunsik Jung; Kyungsuk Kim; Sookyung Lee; Seongwoo Yoon; Jaehyun Park; Sehyun Kim; Seongha Cheon; Wankyo Eo; Sanghun Lee
Journal:  J Biomed Biotechnol       Date:  2011-11-17

Review 3.  Integrating traditional medicine into modern inflammatory diseases care: multitargeting by Rhus verniciflua Stokes.

Authors:  Ji Hye Kim; Yong Cheol Shin; Seong-Gyu Ko
Journal:  Mediators Inflamm       Date:  2014-06-12       Impact factor: 4.711

4.  Novel silkworm (Bombyx mori) sulfotransferase swSULT ST3 is involved in metabolism of polyphenols from mulberry leaves.

Authors:  Kohji Yamamoto; Naotaka Yamada; Satoshi Endo; Katsuhisa Kurogi; Yoichi Sakakibara; Masahito Suiko
Journal:  PLoS One       Date:  2022-08-04       Impact factor: 3.752

Review 5.  Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment.

Authors:  Li Huang; Rongzhang He; Weihao Luo; Yuan-Shan Zhu; Jia Li; Tan Tan; Xi Zhang; Zheng Hu; Dixian Luo
Journal:  Recent Pat Anticancer Drug Discov       Date:  2016       Impact factor: 4.169
  5 in total

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